SCHEMBL12533859

SCHEMBL12533859

CCCc1cccc(N(c2ccc(-c3ccccc3)cc2)c2cccc(CCC)c2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTB4R2 Q9NPC1 1/20 0.40
KDM4E B2RXH2 2/20 0.40
ALDH1A1 P00352 2/20 0.40
MAPT P10636 2/20 0.40
NPC1 O15118 1/20 0.40
PKM P14618 1/20 0.40
HPGD P15428 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
HSD17B10 Q99714 1/20 0.40
DRD2 P14416 2/20 0.39
OPRM1 P35372 2/20 0.39
DRD3 P35462 2/20 0.39
OPRD1 P41143 2/20 0.39
OPRK1 P41145 2/20 0.39
MCL1 Q07820 1/20 0.39
KIF11 P52732 1/20 0.38
TAAR1 Q96RJ0 2/20 0.38
CTSS P25774 1/20 0.38
CTSK P43235 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12922775 0.98 DRD3 (0.40) LTB4R2KDM4EALDH1A1MAPTNPC1
SCHEMBL19670694 0.91 DRD3 (0.44) KDM4EALDH1A1MAPTDRD2OPRM1
SCHEMBL12922779 0.89 LPL (0.44) LTB4R2DRD2OPRM1DRD3OPRD1
SCHEMBL22053558 0.89 MCL1 (0.48) LTB4R2KDM4EALDH1A1MAPTNPC1
SCHEMBL17986879 0.86 BCL2 (0.50) KDM4EALDH1A1MAPTTAAR1BCL2
SCHEMBL12533849 0.86 BCL2 (0.50) KDM4EALDH1A1MAPTTAAR1BCL2
SCHEMBL11887469 0.86 TAAR1 (0.47) LTB4R2KDM4EALDH1A1MAPTNPC1
SCHEMBL14461270 0.86 TAAR1 (0.47) LTB4R2KDM4EALDH1A1MAPTNPC1
SCHEMBL11887114 0.86 RARB (0.43) HSD17B10MCL1TSHR
SCHEMBL17470380 0.85 SIGMAR1 (0.43) KDM4EALDH1A1MAPTOPRM1DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7955768-B2 Electrophotographic photoconductor and method for producing the same, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2011-06-07 US disclosed
US-7955768-B2 Electrophotographic photoconductor and method for producing the same, image forming apparatus, and process cartridge RICOH COMPANY, LTD. (JP) 2011-06-07 US disclosed
US-20090035017-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR AND METHOD FOR PRODUCING THE SAME, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2009-02-05 US disclosed
US-20090035017-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR AND METHOD FOR PRODUCING THE SAME, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2009-02-05 US disclosed