SCHEMBL12533909

SCHEMBL12533909

CNc1c(N)cncc1F

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AOC1 P19801 1/20 0.32
AOC3 Q16853 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16765194 0.74 IKBKE (0.36) AOC1AOC3
SCHEMBL12533687 0.74 GAA (0.40) AOC1AOC3
SCHEMBL1921036 0.71 CYP11B1 (0.39)
SCHEMBL23619884 0.71 RPS6KA3 (0.33)
SCHEMBL17485467 0.70
SCHEMBL24595059 0.70 CYP11B2 (0.34) AOC3
SCHEMBL13482301 0.69
Hydrochloric Acid SCHEMBL30612308 0.67 AOC1 (0.32) AOC1AOC3
Hydrochloric Acid SCHEMBL26921992 0.67 AOC1 (0.32) AOC1AOC3
SCHEMBL31302357 0.67 KAT2B (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2099796-B1 AZA-INDOLYL COMPOUNDS AND METHODS OF USE GENENTECH INC (US) 2011-06-01 EP disclosed
WO-2008067481-A1 AZA-INDOLYL COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2008-06-05 WO disclosed