AOC1

Diamine oxidase [copper-containing] · P19801 · AOC1 on Sugi Atlas →

5,233 patent compounds predicted against AOC1, 2,150 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL3814561)	1.00	12/20
SCHEMBL2642640	0.57	12/20
SCHEMBL3069406	0.57	12/20
Hydrochloric Acid (SCHEMBL1964470)	0.50	11/20
Hydrochloric Acid (SCHEMBL1013332)	0.44	10/20
SCHEMBL4893069	0.53	9/20
Hydrochloric Acid (SCHEMBL2888606)	0.52	9/20
SCHEMBL6911269	0.51	9/20
SCHEMBL507313	0.48	9/20
SCHEMBL2268998	0.61	8/20
SCHEMBL2479238	0.52	7/20
SCHEMBL7014746	0.52	7/20
SCHEMBL4483018	0.48	7/20
Ammonia Solution, Strong (SCHEMBL3984283)	0.65	6/20
SCHEMBL1979284	0.61	6/20
SCHEMBL4754435	0.57	6/20
SCHEMBL3068769	0.45	6/20
SCHEMBL2090251	0.36	6/20
SCHEMBL3878756	0.36	6/20
Pyridine (SCHEMBL7022106)	0.53	5/20

Clinical trials — most relevant to AOC1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Obeticholic Acid Among Chronic HBV Patients with Hepatic Steatosis : Clinical and Portal Doppler Outcomes	PHASE3	NOT_YET_RECRUITING
Endothelial Dysfunction and Oxidative Stress in Children With Sleep Disordered Breathing.	PHASE1/PHASE2	COMPLETED
Copper Histidine Therapy for Menkes Diseases	PHASE1/PHASE2	COMPLETED
A Phase I/II Open-label Safety and Efficacy Study of LNP.UCD.ABE in Patients With Urea Cycle Disorders.	PHASE1/PHASE2	NOT_YET_RECRUITING
Effect of Acetaminophen and N-Acetylcysteine on Liver Metabolism on Homocystinuria	PHASE1/PHASE2	SUSPENDED
Effects of Angiotensin-Converting Enzyme Inhibitor (Ramipril) Therapy on Blood Vessel Inflammation	PHASE2	COMPLETED
Inhibition of VAP-1 by Caffeine in Healthy Human Volunteers Study	PHASE1	WITHDRAWN
NAC Treatment and Outcomes in Patients With Advanced Atherosclerosis and DM	PHASE1	WITHDRAWN
Prevalence of DAO (diamino Oxidase) Deficiency in Newborns	nan	COMPLETED
Effect of Low Histamine-Based Modified Mediterranean Diet in Multiple Sclerosis	nan	COMPLETED
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN
Genetic DAO Deficiency and Lower Urinary Tract Symptoms	nan	COMPLETED
Personalizing Preterm Neonatal Transfusions With Fetal Hemoglobin-Enriched Cord Blood	nan	NOT_YET_RECRUITING
Effect of Oral L-arginine 3.32 g a Day on Oxidative Stress Influencing Beta Cell Function and Insulin Resistance.	nan	NOT_YET_RECRUITING
Exchangeable and Relative Exchangeable Copper as an Alternative to 24-Hour Urinary Copper in Wilson's Disease Monitoring	nan	COMPLETED
Perfusion - Pressure - Creatinine Trial	nan	COMPLETED
Prebiotic Effects of California Grapes on Gut Health and Cardiometabolic Health in Overweight Men and Women	nan	RECRUITING
Limb Remote Ischemic Preconditioning Reduces Heart and Lung Injury After Abdominal Aortic Aneurysm Repair	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Molecular Epidemiology of Parkinson's Disease	nan	COMPLETED
Hemochromatosis and Iron Overload Screening Study (HEIRS)	nan	COMPLETED
Genetic Determinants of Congenital Heart Disease Outcomes	nan	COMPLETED
MicroRNAs in Renal Recovery - Pilot Study	nan	UNKNOWN
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)	nan	COMPLETED
Optimal Approach for Analysis of Case-Control Genetic Association Studies	nan	COMPLETED
Analysis of the Prognostic Role of Epigenetic Biomarkers in Relation to the Motor Decline in Parkinson's Disease	nan	UNKNOWN
Ginkgo Biloba Extract for Schizophrenia	nan	COMPLETED
Primary Hyperoxaluria Mutation Genotyping/Phenotyping	nan	COMPLETED
Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China	nan	COMPLETED
Oxidative Stress and Haemostasis Abnormalities in Cirrhosis	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a AOC1 binder may also engage these)

Protein	Name	Similarity
P36633	—	1.000	P36633 →
AOC3	Amine oxidase [copper-containing] 3	1.000	landscape →
O70423	—	1.000	O70423 →
Q9TRC7	—	1.000	Q9TRC7 →
Q8JZQ5	—	1.000	Q8JZQ5 →
O08590	—	1.000	O08590 →
Q812C9	—	1.000	Q812C9 →
O46406	—	1.000	O46406 →
Q9TTK6	—	1.000	Q9TTK6 →
AOC2	Amine oxidase [copper-containing] 2	0.999	landscape →
Q5R9I0	—	0.997	Q5R9I0 →
Q29437	—	0.994	Q29437 →
Q2KHV9	—	0.983	Q2KHV9 →
Q9M2B9	—	0.981	Q9M2B9 →
Q9DBX3	—	0.981	Q9DBX3 →
Q9UGT4	—	0.980	Q9UGT4 →
Q28949	—	0.979	Q28949 →
Q5RDJ3	—	0.979	Q5RDJ3 →
P02702	—	0.978	P02702 →
Q8QZW3	—	0.978	Q8QZW3 →
Q96PQ0	—	0.978	Q96PQ0 →
A6QQ07	—	0.977	A6QQ07 →
A0A286YEC0	—	0.977	A0A286YEC0 →
Q09200	—	0.977	Q09200 →
O54782	—	0.977	O54782 →
Q5T197	—	0.976	Q5T197 →
Q16586	—	0.976	Q16586 →
Q2KJC3	—	0.976	Q2KJC3 →
Q68DD2	—	0.976	Q68DD2 →
Q8H1H9	—	0.976	Q8H1H9 →