Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1637305 | 0.85 | CRHR1 (0.37) | CRHR1C5AR1MAP2K7 | |
| SCHEMBL12534738 | 0.85 | CRHR1 (0.37) | CRHR1C5AR1LRRK2 | |
| SCHEMBL1637864 | 0.80 | CRHR1 (0.37) | CRHR1C5AR1MAP2K7 | |
| SCHEMBL1637947 | 0.80 | MAP2K7 (0.42) | CRHR1C5AR1MAP2K7 | |
| SCHEMBL12535216 | 0.79 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL5028599 | 0.78 | CRHR1 (0.36) | CRHR1MAP2K7 | |
| SCHEMBL12534725 | 0.78 | — | — | |
| SCHEMBL1762875 | 0.77 | FFAR4 (0.36) | CRHR1MAP2K7 | |
| SCHEMBL12534724 | 0.77 | CRHR1 (0.39) | CRHR1MAP2K7LRRK2 | |
| SCHEMBL12534734 | 0.75 | CRHR1 (0.32) | CRHR1MAP2K7LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455511-B2 | Pyrrolopyridine derivatives substituted with cyclic amino group | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2013-06-04 | — | — | US | disclosed |
| US-20110130364-A1 | PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH CYCLIC AMINO GROUP | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-06-02 | — | — | US | disclosed |
| US-7932259-B2 | Pyrrolo[2,3-d]pyrimidine derivatives substituted with a cyclic amino group | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-04-26 | — | — | US | disclosed |
| US-20080287397-A1 | Pyrrolopyrimidine Derivatives Substituted with Cyclic Amino Group | TASHO PHARMACEUTICAL CO., LTD. (JP) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287397-A1 | Pyrrolopyrimidine Derivatives Substituted with Cyclic Amino Group | HRH2, HRH4, CRHR1 | CRHR1 3/4885C5AR1 339/4885MAP2K7 1653/4885 |
| US-20110130364-A1 | PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH CYCLIC AMINO GROUP | HRH2, HRH4, CRHR1 | CRHR1 3/4885C5AR1 371/4885MAP2K7 1632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.