Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 3/20 | 0.49 |
| ▸ | PARP1 | P09874 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22292592 | 0.78 | LMNA (0.41) | PDPK1PARP1LMNATSHRADORA2A | |
| SCHEMBL6907428 | 0.77 | LMNA (0.43) | PDPK1PARP1LMNATSHRADORA2A | |
| SCHEMBL20213686 | 0.77 | LMNA (0.43) | PDPK1PARP1LMNATSHRADORA2A | |
| SCHEMBL2902002 | 0.77 | TSHR (0.43) | PDPK1PARP1LMNATSHRADORA2A | |
| SCHEMBL22488626 | 0.77 | CYP1A2 (0.43) | PDPK1PARP1LMNATSHRADORA2A | |
| SCHEMBL28918223 | 0.74 | DYRK1A (0.38) | PDPK1PARP1LMNATSHRADORA2A | |
| SCHEMBL18555761 | 0.73 | BCAT2 (0.42) | PDPK1PARP1LMNATSHRADORA2A | |
| SCHEMBL30947487 | 0.73 | DYRK1A (0.40) | PDPK1PARP1LMNATSHRADORA2A | |
| SCHEMBL7013187 | 0.71 | CYP1A2 (0.56) | PDPK1PARP1LMNATSHRADORA2A | |
| SCHEMBL14190552 | 0.71 | PDPK1 (0.76) | PDPK1PARP1ACHEGDAACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728264-B1 | DIAZAINDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-12-01 | — | — | EP | disclosed |
| US-10544143-B2 | 4-azaindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190185469-A1 | 4-AZAINDOLE COMPOUNDS | SYNGENE INTERNATIONAL LIMITED (IN) | 2019-06-20 | — | — | US | disclosed |
| US-7968554-B2 | Pyrazolo[3,4-d]pyrimidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7968554-B2 | Pyrazolo[3,4-d]pyrimidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-06-28 | — | — | US | disclosed |
| EP-2188290-B1 | PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | HOFFMANN LA ROCHE (CH) | 2011-06-08 | — | — | EP | disclosed |
| US-20090048274-A1 | PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES | BARTKOVITZ DAVID JOSEPH | 2009-02-19 | — | — | US | disclosed |
| US-20090048274-A1 | PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES | BARTKOVITZ DAVID JOSEPH | 2009-02-19 | — | — | US | disclosed |
| WO-2009021869-A1 | PYRAZOLO[3,4-D]-PYRAMIDINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048274-A1 | PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES | BRAF, RAF1, PRKDC | PDPK1 63/4885PARP1 1300/4885LMNA 4341/4885 |
| US-10544143-B2 | 4-azaindole compounds | TLR7, TLR9, TLR5 | PDPK1 1884/4885PARP1 728/4885LMNA 3331/4885 |
| US-20190185469-A1 | 4-AZAINDOLE COMPOUNDS | TLR7, TLR9, TLR5 | PDPK1 1884/4885PARP1 728/4885LMNA 3331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.