SCHEMBL12545765

SCHEMBL12545765

C=CC(=O)Oc1cccc(-c2nc3ccccc3s2)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 13/20 0.62
SMN1; SMN2 Q16637 9/20 0.62
RAB9A P51151 6/20 0.62
NFKB1 P19838 3/20 0.62
NFKB2 Q00653 3/20 0.62
RELA Q04206 3/20 0.62
TDP1 Q9NUW8 2/20 0.62
LMNA P02545 4/20 0.56
TP53 P04637 4/20 0.56
HSD17B10 Q99714 3/20 0.56
POLB P06746 2/20 0.56
KDM4E B2RXH2 6/20 0.53
NPC1 O15118 3/20 0.53
GAA P10253 2/20 0.53
ALDH1A1 P00352 5/20 0.52
MEN1 O00255 4/20 0.52
KMT2A Q03164 4/20 0.52
HPGD P15428 4/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
FFAR1 O14842 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12545487 0.86 RAB9A (0.59) MAPTSMN1; SMN2RAB9ALMNATP53
SCHEMBL14742583 0.85 MAPT (0.69) MAPTSMN1; SMN2RAB9ANFKB1NFKB2
SCHEMBL12545650 0.83 MAPT (0.63) MAPTSMN1; SMN2RAB9ANFKB1NFKB2
SCHEMBL4580118 0.81 MAPT (0.56) MAPTSMN1; SMN2RAB9ATDP1LMNA
SCHEMBL2090792 0.80 RAB9A (0.74) MAPTSMN1; SMN2RAB9ANFKB1NFKB2
SCHEMBL14742582 0.78 FFAR1 (0.71) MAPTSMN1; SMN2RAB9ANFKB1NFKB2
SCHEMBL30161523 0.77 MAPT (1.00) MAPTSMN1; SMN2RAB9ANFKB1NFKB2
SCHEMBL2090795 0.77 MAPT (1.00) MAPTSMN1; SMN2RAB9ANFKB1NFKB2
SCHEMBL12545472 0.77 MEN1 (0.52) MAPTSMN1; SMN2RAB9ATDP1LMNA
SCHEMBL379254 0.76 MEN1 (0.45) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9000111-B2 Thermoplastic resin, organic-inorganic hybrid composition and optical parts FUJIFILM CORPORATION (JP) 2015-04-07 US disclosed
US-9000111-B2 Thermoplastic resin, organic-inorganic hybrid composition and optical parts FUJIFILM CORPORATION (JP) 2015-04-07 US disclosed
US-20110135903-A1 THERMOPLASTIC RESIN, ORGANIC-INORGANIC HYBRID COMPOSITION AND OPTICAL PARTS FUJIFILM CORPORATION (JP) 2011-06-09 US disclosed
US-20110135903-A1 THERMOPLASTIC RESIN, ORGANIC-INORGANIC HYBRID COMPOSITION AND OPTICAL PARTS FUJIFILM CORPORATION (JP) 2011-06-09 US disclosed
WO-2010024463-A1 THERMOPLASTIC RESIN, ORGANIC-INORGANIC HYBRID COMPOSITION AND OPTICAL PARTS FUJIFILM CORPORATION (JP) 2010-03-04 WO disclosed