Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12546068 | 0.97 | HPGD (0.59) | HPGDTSHRPLA2G7HSP90AA1HSP90AB1 | |
| SCHEMBL19185792 | 0.88 | HPGD (0.59) | HPGDTSHRPLA2G7HSP90AA1HSP90AB1 | |
| SCHEMBL12545945 | 0.87 | HSP90AA1 (0.75) | HPGDHSP90AA1HSP90AB1POLBKMT2A | |
| SCHEMBL18929889 | 0.86 | HPGD (0.60) | HPGDTSHRPLA2G7HSP90AA1HSP90AB1 | |
| SCHEMBL24746239 | 0.83 | HSP90AA1 (0.55) | HPGDTSHRPLA2G7HSP90AA1HSP90AB1 | |
| SCHEMBL12569383 | 0.82 | HPGD (0.73) | HPGDTSHRPLA2G7CNR2POLB | |
| SCHEMBL14232145 | 0.81 | HSP90AA1 (0.75) | HSP90AA1HSP90AB1 | |
| SCHEMBL19651827 | 0.81 | HPGD (0.65) | HPGDTSHRHSP90AA1HSP90AB1POLB | |
| SCHEMBL17689127 | 0.80 | HPGD (0.73) | HPGDTSHRPLA2G7CNR2POLB | |
| SCHEMBL15044968 | 0.80 | MEN1 (0.54) | HPGDTSHRPLA2G7HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133037-A1 | MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| US-8987242-B2 | Morpholinone compounds as factor IXA inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20110135650-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2011-06-09 | — | — | US | disclosed |
| US-20110135650-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110135650-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | SERPINC1, F9, F8 | HPGD 3092/4885TSHR 2827/4885PLA2G7 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.