Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739411 | 0.95 | KCNN4 (0.44) | KCNN4TAAR1MAPK1TSHRALDH1A1 | |
| SCHEMBL8780444 | 0.93 | KCNN4 (0.43) | KCNN4TAAR1MAPK1TSHRALDH1A1 | |
| SCHEMBL5591122 | 0.88 | KCNN4 (0.40) | KCNN4TAAR1MAPK1TSHRALDH1A1 | |
| SCHEMBL5590957 | 0.86 | KCNN4 (0.39) | KCNN4TAAR1MAPK1TSHRALDH1A1 | |
| SCHEMBL28128289 | 0.86 | KCNN4 (0.39) | KCNN4TAAR1MAPK1TSHRALDH1A1 | |
| SCHEMBL17082483 | 0.80 | KIF11 (0.50) | KIF11 | |
| SCHEMBL647983 | 0.76 | KCNN4 (0.41) | KCNN4TAAR1MAPK1TSHRCYP2C19 | |
| SCHEMBL6951035 | 0.75 | KCNN4 (0.44) | KCNN4TAAR1MAPK1TSHRALDH1A1 | |
| SCHEMBL15801006 | 0.73 | TAAR1 (0.44) | KCNN4TAAR1MAPK1TSHRALDH1A1 | |
| SCHEMBL14050234 | 0.73 | TAAR1 (0.44) | KCNN4TAAR1MAPK1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110024730-A1 | POLYMER, ORGANIC THIN FILM USING THE SAME, AND ORGANIC THIN FILM DEVICE | SUMITOMO CHEMICAL COMPANY, LIMITED | 2011-02-03 | — | — | US | disclosed |
| EP-2243796-A1 | POLYMER, ORGANIC THIN FILM USING THE SAME, AND ORGANIC THIN FILM DEVICE | Osaka University (JP) | 2010-10-27 | — | — | EP | disclosed |
| US-5478938-A | Antagonists for angiotensin II receptors; hypotensive, cardiotonic agents; cognitive activators | ROUSSEL UCLAF (FR) | 1995-12-26 | — | — | US | disclosed |
| US-5424314-A | Anti-anoxic | ROUSSEL-UCLAF (FR) | 1995-06-13 | — | — | US | disclosed |
| US-5324839-A | Hypotensive agents, gastrointestinal and urogenital disorders | ROUSSEL-UCLAF (FR) | 1994-06-28 | — | — | US | disclosed |