Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12547398 | 0.93 | MET (0.54) | METMAPK14NPC1RAB9ACNR1 | |
| SCHEMBL19267218 | 0.90 | MET (0.52) | METMAPK14NPC1RAB9ACNR1 | |
| SCHEMBL19267191 | 0.90 | MET (0.52) | METMAPK14NPC1RAB9ACNR1 | |
| SCHEMBL12547779 | 0.88 | MET (0.54) | METMAPK14NPC1RAB9ACNR1 | |
| SCHEMBL1581624 | 0.84 | MET (0.54) | METNPC1RAB9ACNR1CNR2 | |
| SCHEMBL1951169 | 0.82 | MET (0.57) | METNPC1RAB9ASRCLTA4H | |
| SCHEMBL19267219 | 0.82 | MET (0.43) | METMAPK14CNR1CNR2LTA4H | |
| SCHEMBL1579474 | 0.81 | MET (0.54) | METNPC1RAB9ASRCLTA4H | |
| SCHEMBL13492824 | 0.81 | MET (0.54) | METNPC1RAB9ASRCLTA4H | |
| SCHEMBL1950388 | 0.81 | MET (0.55) | METNPC1RAB9ALTA4HROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8435986-B2 | Bicyclic traizole derivatives for treating of tumors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-05-07 | — | — | US | disclosed |
| US-20110135600-A1 | BICYCLIC TRAIZOLE DERIVATIVES FOR TREATING OF TUMORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG | 2011-06-09 | — | — | US | disclosed |
| US-20110135600-A1 | BICYCLIC TRAIZOLE DERIVATIVES FOR TREATING OF TUMORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110135600-A1 | BICYCLIC TRAIZOLE DERIVATIVES FOR TREATING OF TUMORS | RET, BMX, ERBB2 | MET 11/4885MAPK14 1591/4885NPC1 4576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.