Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12547398 | 0.93 | MET (0.54) | METSRCMAPK14NPC1RAB9A | |
| SCHEMBL19267219 | 0.92 | MET (0.43) | METMAPK14CNR1CNR2LTA4H | |
| SCHEMBL19267218 | 0.90 | MET (0.52) | METSRCMAPK14NPC1RAB9A | |
| SCHEMBL12547877 | 0.90 | MET (0.52) | METSRCMAPK14NPC1RAB9A | |
| SCHEMBL12547779 | 0.88 | MET (0.54) | METSRCMAPK14NPC1RAB9A | |
| SCHEMBL1951169 | 0.82 | MET (0.57) | METSRCNPC1RAB9ALTA4H | |
| SCHEMBL13492824 | 0.81 | MET (0.54) | METSRCNPC1RAB9ALTA4H | |
| SCHEMBL1579474 | 0.81 | MET (0.54) | METSRCNPC1RAB9ALTA4H | |
| SCHEMBL1581624 | 0.81 | MET (0.54) | METSRCNPC1RAB9ACNR1 | |
| SCHEMBL1950388 | 0.81 | MET (0.55) | METNPC1RAB9ALTA4HROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310013-B1 | BICYCLIC TRIAZOLE DERIVATIVES FOR TREATING TUMORS | MERCK PATENT GMBH (DE) | 2017-08-23 | — | — | EP | disclosed |