Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12554117 | 0.82 | SMN1; SMN2 (0.39) | ALDH1A1LMNAKDM4ESMN1; SMN2CYP3A4 | |
| SCHEMBL12384127 | 0.77 | CYP3A4 (0.38) | ALDH1A1LMNASMN1; SMN2CYP3A4TDP1 | |
| SCHEMBL23582874 | 0.77 | ALDH1A1 (0.39) | ALDH1A1KDM4EMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL6164950 | 0.77 | ALDH1A1 (0.43) | ALDH1A1GAAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL23582894 | 0.76 | ALDH1A1 (0.34) | ALDH1A1LMNASMN1; SMN2CYP3A4TDP1 | |
| SCHEMBL8571227 | 0.74 | CYP3A4 (0.50) | ALDH1A1GAALMNAKDM4EMAPT | |
| SCHEMBL10150788 | 0.73 | CYP3A4 (0.36) | ALDH1A1MAPTSMN1; SMN2CYP3A4TDP1 | |
| SCHEMBL13149255 | 0.71 | CYP3A4 (0.50) | ALDH1A1KDM4EMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL12551873 | 0.70 | CYP3A4 (0.40) | ALDH1A1SMN1; SMN2CYP3A4TDP1L3MBTL1 | |
| SCHEMBL31643470 | 0.70 | NR1H2 (0.44) | KDM4EMAPTSMN1; SMN2CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130196987-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2013-08-01 | — | — | US | disclosed |
| US-8329742-B2 | Macrocyclic compounds useful as pharmaceuticals | EISAI CO., LTD. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | FLT1, TBXA2R, VEGFA | ALDH1A1 1425/4885GAA 1289/4885LMNA 3424/4885 |
| US-20130196987-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | FLT4, VEGFA, FLT1 | ALDH1A1 2336/4885GAA 799/4885LMNA 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.