Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12551873 | 0.85 | CYP3A4 (0.40) | SMN1; SMN2ALDH1A1CYP3A4TDP1L3MBTL1 | |
| SCHEMBL12552829 | 0.82 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1CYP3A4TDP1L3MBTL1 | |
| SCHEMBL12384127 | 0.77 | CYP3A4 (0.38) | SMN1; SMN2ALDH1A1CYP3A4TDP1HPGD | |
| SCHEMBL23582874 | 0.77 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1CYP3A4TDP1HPGD | |
| SCHEMBL15150348 | 0.74 | PTPN1 (0.30) | — | |
| SCHEMBL12552594 | 0.74 | PTPN1 (0.30) | — | |
| SCHEMBL10150788 | 0.73 | CYP3A4 (0.36) | SMN1; SMN2ALDH1A1CYP3A4TDP1HPGD | |
| SCHEMBL23582894 | 0.73 | ALDH1A1 (0.34) | SMN1; SMN2ALDH1A1CYP3A4TDP1L3MBTL1 | |
| SCHEMBL12552808 | 0.72 | CYP3A4 (0.50) | SMN1; SMN2ALDH1A1CYP3A4TDP1L3MBTL1 | |
| SCHEMBL571273 | 0.71 | CYP3A4 (0.61) | SMN1; SMN2ALDH1A1CYP3A4TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | FLT1, TBXA2R, VEGFA | SMN1; SMN2 2503/4885ALDH1A1 1425/4885CYP3A4 1204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.