Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 6/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | STK3 | Q13188 | 1/20 | 0.36 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1932018 | 0.83 | KDM4E (0.43) | LRRK2LMNAJAK2JAK1TYK2 | |
| SCHEMBL1932021 | 0.83 | KDM4E (0.43) | LRRK2LMNAJAK2JAK1TYK2 | |
| SCHEMBL19051344 | 0.74 | AR (0.69) | ARLMNAALDH1A1MAPTHPGD | |
| SCHEMBL5724437 | 0.72 | JAK3 (0.35) | ARJAK2JAK1TYK2JAK3 | |
| SCHEMBL2547518 | 0.72 | HRH3 (0.47) | AR | |
| SCHEMBL2551286 | 0.71 | ALDH1A1 (0.42) | ALDH1A1KDM4EGAAMAPTSMN1; SMN2 | |
| SCHEMBL20298523 | 0.70 | AR (0.43) | ARLRRK2LMNANR3C2F2RL3 | |
| SCHEMBL25361933 | 0.69 | LRRK2 (0.40) | LRRK2STK3STK26NR3C2ALDH1A1 | |
| SCHEMBL21940791 | 0.69 | LRRK2 (0.44) | LRRK2STK3STK26ALDH1A1KDM4E | |
| SCHEMBL21940294 | 0.69 | LRRK2 (0.44) | LRRK2STK3STK26ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011064288-A1 | MORPHOLINOTHIAZOLES AS ALPHA 7 POSITIVE ALLOSTERIC MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-03 | — | — | WO | disclosed |