Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.44 |
| ▸ | STK3 | Q13188 | 1/20 | 0.44 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21940791 | 1.00 | LRRK2 (0.44) | LRRK2STK3STK26ALDH1A1HPGD | |
| SCHEMBL21940800 | 0.83 | KDM4E (0.44) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL21940802 | 0.83 | KDM4E (0.44) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL21940293 | 0.83 | KDM4E (0.44) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL21940582 | 0.83 | KDM4E (0.44) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL21941078 | 0.83 | KDM4E (0.38) | ALDH1A1HPGDKHKFFAR2KDM4E | |
| SCHEMBL21941085 | 0.82 | LRRK2 (0.50) | LRRK2STK3STK26ALDH1A1HPGD | |
| SCHEMBL25361933 | 0.82 | LRRK2 (0.40) | LRRK2STK3STK26ALDH1A1HPGD | |
| SCHEMBL31659922 | 0.81 | LRRK2 (0.35) | LRRK2STK3STK26 | |
| SCHEMBL21940600 | 0.78 | LRRK2 (0.41) | LRRK2STK3STK26FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |