⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6057033 | 0.81 | — | — | |
| SCHEMBL10923677 | 0.81 | — | — | |
| SCHEMBL13225737 | 0.76 | — | — | |
| SCHEMBL3306180 | 0.76 | — | — | |
| SCHEMBL1414374 | 0.75 | LMNA (0.35) | — | |
| Bromide SCHEMBL2350288 | 0.74 | — | — | |
| SCHEMBL716317 | 0.74 | FDPS (0.32) | — | |
| SCHEMBL3310957 | 0.74 | FDPS (0.32) | — | |
| SCHEMBL4658 | 0.73 | — | — | |
| SCHEMBL10445775 | 0.72 | MC4R (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268862-B2 | Sirtuin modulating compounds | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-09-18 | — | — | US | claimed |
| US-8202876-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2012-06-19 | — | — | US | claimed |
| US-20110152254-A1 | SIRTUIN MODULATING COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-06-23 | — | — | US | claimed |
| EP-2170905-A2 | SIRTUIN MODULATING THIAZOLOPYRIDINE COMPOUNDS | Sirtris Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | claimed |
| US-20100029605-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-02-04 | — | — | US | claimed |
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | claimed |
| US-20090105246-A1 | Sirtuin modulating compounds | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-04-23 | — | — | US | claimed |
| WO-2008156869-A2 | SIRTUIN MODULATING THIAZOLOPYRIDINE COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | claimed |
| US-7402583-B2 | Substituted quinolines as antitumor agents | ASTRZENCA AB (SE) | 2008-07-22 | — | — | US | claimed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | claimed |
| US-20070021407-A1 | Substituted quinolines as antitumor agents | ASTRAZENECA | 2007-01-25 | — | — | US | claimed |
| US-20040029898-A1 | Substituted quinolines as antitumor agents | ASTRAZENECA AB (SE) | 2004-02-12 | — | — | US | claimed |
| EP-1337524-A1 | SUBSTITUTED QUINOLINES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2003-08-27 | — | — | EP | claimed |
| WO-2002044166-A1 | SUBSTITUTED QUINOLINES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2002-06-06 | — | — | WO | claimed |
| US-10383837-B2 | Compositions and methods for modulating metabolic pathways | NUSIRT SCIENCES, INC. (US) | 2019-08-20 | — | — | US | disclosed |
| US-20190224152-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | NUMETA SCIENCES, INC. | 2019-07-25 | — | — | US | disclosed |
| EP-3466418-A1 | COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS | NuSirt Sciences, Inc. (US) | 2019-04-10 | — | — | EP | disclosed |
| WO-2003020721-A1 | PYRROLO PYRIMIDINES AS AGENTS FOR THE INHIBITION OF CYSTEIN PROTEASES | NOVARTIS AG (CH) | 2003-03-13 | — | — | WO | disclosed |
| EP-1286997-A1 | 6-PHENYLPYRROLOPYRIMIDINEDIONE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001094350-A1 | 6-PHENYLPYRROLOPYRIMIDINEDIONE DERIVATIVES | ALMIRALL PRODESFARMA S.A. (ES) | 2001-12-13 | — | — | WO | disclosed |