Tocladesine

Tocladesine

SCHEMBL125595

Nc1ncnc2c1nc(Cl)n2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ PDE4A P27815 15/20 1.00
▸ PDE4B Q07343 15/20 1.00
▸ PDE4C Q08493 15/20 1.00
▸ PDE4D Q08499 15/20 1.00
▸ PRKACA P17612 1/20 0.73
▸ PRKACG P22612 1/20 0.73
▸ PRKACB P22694 1/20 0.73
▸ STING1 Q86WV6 2/20 0.68
▸ LMNA P02545 2/20 0.68
▸ GMNN O75496 1/20 0.68
▸ RAPGEF3 O95398 1/20 0.68
▸ BLM P54132 1/20 0.68
▸ KMT2A Q03164 1/20 0.68
▸ NPSR1 Q6W5P4 1/20 0.68
▸ RAPGEF4 Q8WZA2 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tocladesine SCHEMBL29381763 1.00 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPRKACA
Tocladesine SCHEMBL1651488 1.00 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPRKACA
SCHEMBL9702440 0.90 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPRKACA
SCHEMBL5951342 0.89 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPRKACA
SCHEMBL29384358 0.89 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPRKACA
SCHEMBL14261298 0.89 PDE4A (0.82) PDE4APDE4BPDE4CPDE4DPRKACA
SCHEMBL29359388 0.89 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPRKACA
SCHEMBL9505216 0.89 PDE4A (0.82) PDE4APDE4BPDE4CPDE4DPRKACA
SCHEMBL2713659 0.89 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPRKACA
SCHEMBL16079734 0.89 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPRKACA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1542 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4704904-A1 TETRAZINE-BASED TARGETING AGENTS FOR IN VIVO DELIVERY OF A PAYLOAD Tambo, Inc. (US) 2026-03-11 — — EP claimed
EP-4687964-A2 METHOD OF VACCINATING FOR CANCER AND DEVICE AND KIT THEREFOR Purdue Research Foundation (US) 2026-02-11 — — EP claimed
EP-4627061-A1 CULTURE MEDIUM, COATING MATRIX AND METHOD FOR MATURING MIDBRAIN DOPAMINERGIC PROGENITOR CELLS Nuwacell Biotechnologies Co., Ltd. (CN) 2025-10-08 — — EP claimed
US-12391919-B2 Culture medium, coating matrix and method for maturing midbrain dopaminergic progenitor cells NUWACELL BIOTECHNOLOGIES CO., LTD. (CN) 2025-08-19 — — US claimed
US-20250207092-A1 CULTURE MEDIUM, COATING MATRIX AND METHOD FOR MATURING MIDBRAIN DOPAMINERGIC PROGENITOR CELLS NUWACELL BIOTECHNOLOGIES CO., LTD. (CN) 2025-06-26 — — US claimed
WO-2024229427-A1 TETRAZINE-BASED TARGETING AGENTS FOR IN VIVO DELIVERY OF A PAYLOAD TAMBO, INC. (US) 2024-11-07 — — WO claimed
WO-2024207006-A2 METHOD OF VACCINATING FOR CANCER AND DEVICE AND KIT THEREFOR PURDUE RESEARCH FOUNDATION (US) 2024-10-03 — — WO claimed
EP-4427588-A2 COMPOSITIONS FOR HEMOLYSIS AND COAGULATION REGULATION AND STABILIZATION OF EXTRACELLULAR VESICLES Streck LLC (US) 2024-09-11 — — EP claimed
EP-4422696-A1 TETRAZINE CONJUGATES FOR IN VIVO TARGETED DELIVERY OF A PAYLOAD Tambo, Inc. (US) 2024-09-04 — — EP claimed
CN-115119829-B Compositions for the modulation of haemolysis and coagulation of extracellular vesicles and stabilization 斯特雷克股份有限公司 2024-07-12 — — CN claimed
WO-2003065994-A2 SCHWANN CELL AND PHOSPHODIESTERASE INHIBITORS BASED THERAPY UNIVERSITY OF MIAMI (US) 2003-08-14 — — WO claimed
US-20030134821-A1 Promoters of neural regeneration NIH-DEITR 2003-07-17 — — US claimed
US-20030134820-A1 Promoters of neural regeneration NIH-DEITR 2003-07-17 — — US claimed
US-6284539-B1 IDENTIFYING CELLS EXPRESSING TYROSINE HYDROXYLASE; INCUBATING STEM CELLS WITH POLYNUCLEOTIDE ENCODING TRANSCRIPTION REGULATOR; PARKINSON'S DISEASE; DOPAMINERGIC CELL FATE NEURALSTEM BIOPHARMACEUTICALS, LTD. 2001-09-04 — — US claimed
US-6268352-B1 Promoters of neural regeneration THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2001-07-31 — — US claimed
EP-1109561-A1 PROMOTERS OF NEURAL REGENERATION The Regents of the University of California (US) 2001-06-27 — — EP claimed
WO-2000012099-A1 PROMOTERS OF NEURAL REGENERATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-03-09 — — WO claimed
WO-1999032605-A1 METHOD FOR PRODUCING HETEROLOGOUS PROTEINS IN EUKARYOTIC CELLS ON AN INDUSTRIAL SCALE USING NUCLEOTIDE-MANIPULATING AGENTS NOVO NORDISK A/S (DK) 1999-07-01 — — WO claimed
US-5693521-A USING ACETOXYALKYL ESTER OF ADENOSINE(OR GUANOSINE)-3',5'-CYCLIC MONNOPHOSPHATE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-12-02 — — US claimed
WO-1994023724-A1 MEMBRANE-PERMEANT SECOND MESSENGERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1994-10-27 — — WO claimed
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