Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 13/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 13/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 13/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.81 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.81 |
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.81 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.81 |
| ▸ | PRKACA | P17612 | 1/20 | 0.70 |
| ▸ | PRKACG | P22612 | 1/20 | 0.70 |
| ▸ | PRKACB | P22694 | 1/20 | 0.70 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713659 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL29384358 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL29359388 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL13300468 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL16079734 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL9702440 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL13300472 | 0.90 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL15906331 | 0.90 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL29381703 | 0.90 | RAPGEF3 (1.00) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL1106661 | 0.90 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646395-B1 | METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY | CURIS INC (US) | 2014-11-05 | — | — | EP | disclosed |
| US-20130085096-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-04-04 | — | — | US | disclosed |
| US-20130085096-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-04-04 | — | — | US | disclosed |
| US-8304531-B2 | Process for the preparation of an (RP)-8-substituted cAMPS | SOLVELL AS (NO) | 2012-11-06 | — | — | US | disclosed |
| US-20120238500-A1 | REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | CURIS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| US-20120238500-A1 | REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | CURIS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| US-8168178-B2 | Methods and compositions for regulating lymphocyte activity | CURIS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168178-B2 | Methods and compositions for regulating lymphocyte activity | CURIS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-20110124580-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-05-26 | — | — | US | disclosed |
| US-20100137237-A1 | PROCESS FOR THE PREPARATION OF AN (RP)-8-SUBSTITUTED CAMPS | LAURAS AS (NO) | 2010-06-03 | — | — | US | disclosed |
| US-7691593-B2 | Regulation of lung tissue by patched therapeutics and formulations and uses related thereto | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-04-06 | — | — | US | disclosed |
| US-7691593-B2 | Regulation of lung tissue by patched therapeutics and formulations and uses related thereto | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-04-06 | — | — | US | disclosed |
| US-20090118187-A1 | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto | ONTOGENY, INC. | 2009-05-07 | — | — | US | disclosed |
| US-20070254364-A1 | Methods and compositions for treating disorders involving excitotoxicity | GALDES ALPHONSE | 2007-11-01 | — | — | US | disclosed |
| US-20070254364-A1 | Methods and compositions for treating disorders involving excitotoxicity | GALDES ALPHONSE | 2007-11-01 | — | — | US | disclosed |
| US-20070110698-A1 | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto | WANG ELIZABETH A | 2007-05-17 | — | — | US | disclosed |
| US-20070110698-A1 | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto | WANG ELIZABETH A | 2007-05-17 | — | — | US | disclosed |
| EP-1743903-A2 | Methods and compositions for treating disorders involving excitotoxicity | Curis, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238500-A1 | REGULATION OF EPITHELIAL TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | SHH, SMO, GLI1 | PDE4A 1367/4885PDE4B 1469/4885PDE4C 1110/4885 |
| US-20130085096-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | SHH, FGF1, HGF | PDE4A 1791/4885PDE4B 1807/4885PDE4C 1576/4885 |
| US-20070110698-A1 | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto | SHH, HDGF, HGF | PDE4A 1785/4885PDE4B 2149/4885PDE4C 1417/4885 |
| US-20100137237-A1 | PROCESS FOR THE PREPARATION OF AN (RP)-8-SUBSTITUTED CAMPS | AMPD3, ATIC, PDE8A | PDE4A 31/4885PDE4B 53/4885PDE4C 38/4885 |
| US-20110124580-A1 | REGULATION OF LUNG TISSUE BY HEDGEHOG-LIKE POLYPEPTIDES, AND FORMULATIONS AND USES RELATED THERETO | SHH, FGF1, HGF | PDE4A 1864/4885PDE4B 1933/4885PDE4C 1702/4885 |
| US-20070254364-A1 | Methods and compositions for treating disorders involving excitotoxicity | GRIK5, GRIK3, GRIK4 | PDE4A 2172/4885PDE4B 1971/4885PDE4C 2176/4885 |
| US-20090118187-A1 | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto | SHH, SMO, GLI1 | PDE4A 1367/4885PDE4B 1469/4885PDE4C 1110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.