Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI1 | Q9ULC6 | 5/20 | 0.52 |
| ▸ | PADI4 | Q9UM07 | 5/20 | 0.52 |
| ▸ | PADI2 | Q9Y2J8 | 4/20 | 0.52 |
| ▸ | PDE4A | P27815 | 3/20 | 0.52 |
| ▸ | PADI3 | Q9ULW8 | 3/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | PADI6 | Q6TGC4 | 1/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.44 |
| ▸ | CTSG | P08311 | 3/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.44 |
| ▸ | CMA1 | P23946 | 3/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12560110 | 0.93 | PADI1 (0.56) | PADI1PADI4PADI2PDE4APADI3 | |
| SCHEMBL12598888 | 0.88 | PADI1 (0.59) | PADI1PADI4PADI2PDE4APADI3 | |
| SCHEMBL12598887 | 0.87 | PADI1 (0.58) | PADI1PADI4PADI2PDE4APADI3 | |
| SCHEMBL12598885 | 0.87 | PADI1 (0.54) | PADI1PADI4PADI2PDE4APADI3 | |
| SCHEMBL20138329 | 0.81 | PADI4 (0.63) | PADI1PADI4PADI2PDE4APADI3 | |
| SCHEMBL1979577 | 0.81 | PADI4 (0.63) | PADI1PADI4PADI2PDE4APADI3 | |
| SCHEMBL1979695 | 0.80 | PADI4 (0.62) | PADI1PADI4PADI2PDE4APADI3 | |
| SCHEMBL19581174 | 0.80 | PADI4 (0.62) | PADI1PADI4PADI2PDE4APADI3 | |
| SCHEMBL13560779 | 0.80 | PADI4 (0.55) | PADI1PADI4PADI2PDE4APADI3 | |
| SCHEMBL158990 | 0.79 | PADI1 (0.60) | PADI1PADI4PADI2PDE4APADI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964636-B2 | Synthesis and use of novel inhibitors and inactivators of protein arginine deiminases | UNIVERSITY OF SOUTH CAROLINA (US) | 2011-06-21 | — | — | US | disclosed |
| US-20090306153-A1 | SYNTHESIS AND USE OF NOVEL INHIBITORS AND INACTIVATORS OF PROTEIN ARGININE DEIMINASES | UNIVERSITY OF SOUTH CAROLINA (US) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306153-A1 | SYNTHESIS AND USE OF NOVEL INHIBITORS AND INACTIVATORS OF PROTEIN ARGININE DEIMINASES | PADI1, PADI4, PADI2 | PADI1 1/4885PADI4 2/4885PADI2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.