PADI1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1979695	0.62	8/20
SCHEMBL1981102	0.65	7/20
SCHEMBL1979577	0.63	7/20
SCHEMBL12598887	0.58	7/20
SCHEMBL13560779	0.55	7/20
SCHEMBL1979621	0.66	6/20
SCHEMBL158990	0.60	6/20
SCHEMBL10946109	0.60	6/20
SCHEMBL2569798	0.62	5/20
SCHEMBL4181143	0.62	5/20
SCHEMBL12598888	0.59	5/20
SCHEMBL10518630	0.58	5/20
SCHEMBL12560110	0.56	5/20
Hydrochloric Acid (SCHEMBL16223217)	0.56	5/20
SCHEMBL7200795	0.55	5/20
SCHEMBL3190128	0.55	5/20
SCHEMBL5569820	0.55	5/20
SCHEMBL12598885	0.54	5/20
SCHEMBL7199412	0.54	5/20
SCHEMBL15231556	0.53	5/20

Clinical trials — most relevant to PADI1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
L-Arginine Role for Stone Lower Ureter : A Randomized Control Study	PHASE4	COMPLETED
L-arginine Treatment in Mild Hypertension	PHASE4	UNKNOWN
Vascular Function Intervention Trial in Sickle Cell Disease	PHASE2/PHASE3	UNKNOWN
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial	PHASE3	COMPLETED
L-Arginine in Pre-Eclampsia	PHASE3	COMPLETED
Effect of Rosiglitazone on ADMA in Critical Illness	PHASE3	UNKNOWN
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis	PHASE2	RECRUITING
Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19	PHASE2	COMPLETED
ADI-PEG20, Obesity and Prediabetes	PHASE2	WITHDRAWN
The Effects of NOx and Conjugated Linoleic Acid on Asthmatics	PHASE2	COMPLETED
Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients	PHASE2	COMPLETED
Arginase-1 Peptide Vaccine in Patients With Metastatic Solid Tumors	PHASE1	COMPLETED
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation.	EARLY_PHASE1	COMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
Effect of Nonsurgical Periodontal Therapy (NSPT) on Rheumatoid Arthritis Subjects With Periodontitis	nan	COMPLETED
Serum Anti-PCOLCE as Novel Diagnostic Biomarker in Rheumatoid Arthritis With Emphasis on Seronegative Patients.	nan	NOT_YET_RECRUITING
Study of the Articular Microbiota in Rheumatoid Arthritis.	nan	COMPLETED
Impact of Antiglycemic & Immunosuppressive Therapies on NETosis in Diabetes & Kidney Disease (NETs - Neutrophil Traps)	nan	RECRUITING
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
Effects of Trehalose and Polyphenols in Vasculopathic Patients	nan	COMPLETED
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD	nan	COMPLETED
Arginine Synthesis in Healthy Adult Humans	nan	COMPLETED
Study of Arginine and Nitric Oxide in Patients With Diabetes	nan	COMPLETED
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial	nan	COMPLETED
Effect Assessment of Periodontal Prophylaxis on Rheumatoid Arthritis Activity.	nan	COMPLETED
Full Mouth Disinfection and Antibiotics for Periodontitis in High or Moderate Disease Activity Rheumatoid Arthritis	nan	COMPLETED
L-Arginine, Symmetrical and Asymmetrical Dimethylarginine (SDMA/ADMA) in Acute Kidney Injury (AKI)	nan	COMPLETED
Arginase Inhibition in Type 1 and Type 2 Diabetes Mellitus	nan	COMPLETED
Preterm Arginine INTake Study	nan	COMPLETED
Effect of L-Citrulline Supplementation on Arginase Activity and Vascular Function in Diabetes	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a PADI1 binder may also engage these)

Protein	Name	Similarity
PADI2	Protein-arginine deiminase type-2	1.000	landscape →
O88807	—	1.000	O88807 →
P20717	—	1.000	P20717 →
PADI4	Protein-arginine deiminase type-4	1.000	landscape →
O88806	—	1.000	O88806 →
Q9Z184	—	1.000	Q9Z184 →
Q08642	—	1.000	Q08642 →
Q9Z185	—	1.000	Q9Z185 →
Q8K3V4	—	0.998	Q8K3V4 →
PADI3	Protein-arginine deiminase type-3	0.998	landscape →
O02849	—	0.998	O02849 →
Q9Z183	—	0.996	Q9Z183 →
P70708	—	0.995	P70708 →
PADI6	Inactive protein-arginine deiminase type-6	0.994	landscape →
Q9STV0	—	0.988	Q9STV0 →
Q9D5Z5	—	0.988	Q9D5Z5 →
AS3MT	Arsenite methyltransferase	0.987	landscape →
P06623	—	0.987	P06623 →
KDM5D	Lysine-specific demethylase 5D	0.987	landscape →
KDM5B	Lysine-specific demethylase 5B	0.986	landscape →
A8E7C5	—	0.986	A8E7C5 →
Q8BJM7	—	0.986	Q8BJM7 →
Q8VHT6	—	0.986	Q8VHT6 →
Q5XUN4	—	0.985	Q5XUN4 →
TRPV1	Transient receptor potential cation channel subfamily V member 1	0.985	landscape →
Q95JI2	—	0.985	Q95JI2 →
B8JKF4	—	0.985	B8JKF4 →
A6NC97	—	0.985	A6NC97 →
Q5I3B2	—	0.985	Q5I3B2 →
Q5F3R2	—	0.985	Q5F3R2 →