Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.62 |
| ▸ | GCGR | P47871 | 5/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | FRK | P42685 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16292225 | 0.83 | MAPK13 (0.85) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL1629037 | 0.83 | MAPK13 (0.85) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL85099 | 0.82 | MAPK13 (0.68) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL12858561 | 0.79 | MAPK13 (0.65) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5759775 | 0.79 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4552316 | 0.77 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL29884681 | 0.77 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9195042 | 0.77 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL29642917 | 0.76 | PTPN1 (0.66) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7159987 | 0.76 | PTPN1 (0.66) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150374669-A1 | ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS | LORUS THERAPEUTICS INC. (CA) | 2015-12-31 | — | — | US | disclosed |
| US-20150374669-A1 | ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS | LORUS THERAPEUTICS INC. (CA) | 2015-12-31 | — | — | US | disclosed |
| US-8987305-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | APTOSE BIOSCIENCES INC. (CA) | 2015-03-24 | — | — | US | disclosed |
| US-8987305-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | APTOSE BIOSCIENCES INC. (CA) | 2015-03-24 | — | — | US | disclosed |
| US-8969372-B2 | Aryl imidazoles and their use as anti-cancer agents | Aptose Boisciences Inc. (CA) | 2015-03-03 | — | — | US | disclosed |
| US-8969372-B2 | Aryl imidazoles and their use as anti-cancer agents | Aptose Boisciences Inc. (CA) | 2015-03-03 | — | — | US | disclosed |
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | APTOSE BIOSCIENCES INC. (CA) | 2013-07-11 | — | — | US | disclosed |
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | APTOSE BIOSCIENCES INC. (CA) | 2013-07-11 | — | — | US | disclosed |
| US-8394815-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | LORUS THERAPEUTICS INC. (CA) | 2013-03-12 | — | — | US | disclosed |
| US-8394815-B2 | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents | LORUS THERAPEUTICS INC. (CA) | 2013-03-12 | — | — | US | disclosed |
| US-20110152337-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | LORUS THERAPEUTICS INC. (CA) | 2011-06-23 | — | — | US | disclosed |
| US-20110152337-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | LORUS THERAPEUTICS INC. (CA) | 2011-06-23 | — | — | US | disclosed |
| US-7884120-B2 | microbiocides such as 2-(2-methyl-1H-indol-3-yl)-3a,11b-dihydro-1H-phenanthro[9,10-d]imidazole; bactericides; fungicides | LORUS THERAPEUTICS INC. (CA) | 2011-02-08 | — | — | US | disclosed |
| US-7884120-B2 | microbiocides such as 2-(2-methyl-1H-indol-3-yl)-3a,11b-dihydro-1H-phenanthro[9,10-d]imidazole; bactericides; fungicides | LORUS THERAPEUTICS INC. (CA) | 2011-02-08 | — | — | US | disclosed |
| US-20080262015-A9 | Aryl imidazoles and their use as anti-cancer agents | LORUS THERAPEUTICS INC. (CA) | 2008-10-23 | — | — | US | disclosed |
| US-20080262015-A9 | Aryl imidazoles and their use as anti-cancer agents | LORUS THERAPEUTICS INC. (CA) | 2008-10-23 | — | — | US | disclosed |
| US-20070123553-A1 | Aryl imidazoles and their use as anti-cancer agents | LORUS THERAPEUTICS INC. (CA) | 2007-05-31 | — | — | US | disclosed |
| US-20070123553-A1 | Aryl imidazoles and their use as anti-cancer agents | LORUS THERAPEUTICS INC. (CA) | 2007-05-31 | — | — | US | disclosed |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | APTOSE BIOSCIENCES INC. (CA) | 2007-05-10 | — | — | US | disclosed |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | APTOSE BIOSCIENCES INC. (CA) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130177632-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | IDO2, ERG28, IL4 | MAPK14 2550/4885MAPK13 3668/4885MAPK12 3161/4885 |
| US-20110152337-A1 | 2,4,5-TRISUBSTITUTED IMIDAZOLES AND THEIR USE AS ANTI-MICROBIAL AGENTS | IDO2, ERG28, IL4 | MAPK14 2550/4885MAPK13 3668/4885MAPK12 3161/4885 |
| US-20070123553-A1 | Aryl imidazoles and their use as anti-cancer agents | AHR, AADAC, CBR3 | MAPK14 3469/4885MAPK13 4059/4885MAPK12 3204/4885 |
| US-20150374669-A1 | ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS | AHR, CBR3, AADAC | MAPK14 3647/4885MAPK13 4087/4885MAPK12 3446/4885 |
| US-20070105929-A1 | 2, 4, 5 - Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents | IDO2, ERG28, IL4 | MAPK14 2550/4885MAPK13 3668/4885MAPK12 3161/4885 |
| US-20080262015-A9 | Aryl imidazoles and their use as anti-cancer agents | AHR, AADAC, CBR3 | MAPK14 3469/4885MAPK13 4059/4885MAPK12 3204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.