SCHEMBL1256178

SCHEMBL1256178

Nc1ccc(-c2cnc(N)nc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.70
MEN1 O00255 3/20 0.70
KMT2A Q03164 3/20 0.70
NPC1 O15118 3/20 0.70
RAB9A P51151 3/20 0.70
ALDH1A1 P00352 2/20 0.70
TP53 P04637 2/20 0.70
HSD17B10 Q99714 2/20 0.70
KDM4E B2RXH2 1/20 0.70
HPGD P15428 1/20 0.70
SMN1; SMN2 Q16637 1/20 0.70
CYP3A4 P08684 3/20 0.58
TDP1 Q9NUW8 2/20 0.58
MAP4K4 O95819 2/20 0.56
LMNA P02545 1/20 0.55
TAAR1 Q96RJ0 2/20 0.48
ALOX5AP P20292 1/20 0.41
FEN1 P39748 1/20 0.41
KIF11 P52732 1/20 0.41
PRKCZ Q05513 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4859450 0.83 MAP4K4 (0.56) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL15614090 0.82 MAP4K4 (0.59) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL19742855 0.82 RAB9A (1.00) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL5321375 0.80 MAP4K4 (0.67) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL1198596 0.80 NPC1 (0.55) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL12193535 0.80 MAPT (0.52) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL9613271 0.80 LMNA (0.52) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL1951940 0.80 MAPT (0.52) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL12869440 0.80 MAPT (0.47) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL398019 0.79 MAP4K4 (0.61) MAPTMEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120132069-A Medical polyimide catheter with developing function and preparation method and application thereof 宁波琳盛高分子材料有限公司 2025-06-13 CN claimed
CN-118852621-A Polyimide compound, medical polyimide catheter, and preparation methods and applications thereof 宁波琳盛高分子材料有限公司 2024-10-29 CN claimed
CN-118846246-A Medical polyimide catheter and preparation method and application thereof 宁波琳盛高分子材料有限公司 2024-10-29 CN claimed
CN-103305961-A Production method of polyimide and carbon nanotube composite fibers CHANGCHUN APPLIED CHEMISTRY 2013-09-18 CN claimed
CN-1733736-A Nitrogenous fragrant heterocyclic diamine and preparation method thereof CHANGCHUN APPLIED CHEMISTRY (CN) 2006-02-15 CN claimed
CN-120132069-A Medical polyimide catheter with developing function and preparation method and application thereof 宁波琳盛高分子材料有限公司 2025-06-13 CN disclosed
CN-118852621-A Polyimide compound, medical polyimide catheter, and preparation methods and applications thereof 宁波琳盛高分子材料有限公司 2024-10-29 CN disclosed
CN-118846246-A Medical polyimide catheter and preparation method and application thereof 宁波琳盛高分子材料有限公司 2024-10-29 CN disclosed
CN-113999527-B Resin composition, composite resin, preparation and application thereof 广东粤港澳大湾区黄埔材料研究院 2023-07-18 CN disclosed
CN-113999527-A Resin composition, composite resin, and preparation and application thereof 广东粤港澳大湾区黄埔材料研究院 2022-02-01 CN disclosed
CN-105671671-B Preparation method of polyimide fiber containing symmetric bipyrimidine structure 东华大学 2018-08-03 CN disclosed
CN-103305961-B A kind of preparation method of polyimides-carbon nano tube composite fibre 中国科学院长春应用化学研究所 2016-07-06 CN disclosed
US-20130035326-A1 BIARYL COMPOUNDS AND METHODS OF USE THEREOF AMBIT BIOSCIENCES CORPORATION (US) 2013-02-07 US disclosed
EP-2467137-A1 BIARYL COMPOUNDS AND METHODS OF USE THEREOF Ambit Biosciences Corporation (US) 2012-06-27 EP disclosed
CN-102470127-A Biaryl compounds and methods of use thereof AMBIT BIOSCIENCES CORP 2012-05-23 CN disclosed
EP-1966151-B1 POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS SCHERING CORP (US) 2011-10-05 EP disclosed
WO-2011022473-A1 BIARYL COMPOUNDS AND METHODS OF USE THEREOF AMBIT BIOSCIENCES CORPORATION (US) 2011-02-24 WO disclosed
EP-1984331-B1 PYRROLIDINE DERIVATIVES AS ERK INHIBITORS SCHERING CORP (US) 2010-10-20 EP disclosed
CN-1733736-A Nitrogenous fragrant heterocyclic diamine and preparation method thereof CHANGCHUN APPLIED CHEMISTRY (CN) 2006-02-15 CN disclosed
CN-1733736-A Nitrogenous fragrant heterocyclic diamine and preparation method thereof CHANGCHUN APPLIED CHEMISTRY (CN) 2006-02-15 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130035326-A1 BIARYL COMPOUNDS AND METHODS OF USE THEREOF FLT3, CSF3R, CSF1R MAPT 3602/4885MEN1 1373/4885KMT2A 293/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.