⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29022426 | 0.84 | RAB9A (0.50) | — | |
| SCHEMBL3009475 | 0.81 | — | — | |
| SCHEMBL171892 | 0.79 | — | — | |
| SCHEMBL1109836 | 0.79 | — | — | |
| SCHEMBL5929452 | 0.79 | — | — | |
| SCHEMBL13113182 | 0.76 | RAB9A (0.54) | — | |
| SCHEMBL9912435 | 0.76 | GAPDH (0.58) | — | |
| SCHEMBL10271297 | 0.76 | RAB9A (0.63) | — | |
| SCHEMBL13149779 | 0.76 | GAPDH (0.57) | — | |
| SCHEMBL1428340 | 0.75 | GAPDH (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373261-A2 | CYCLOPROPAHETEROCYCLES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MEDIVIR AB (SE) | 2004-01-02 | — | — | EP | claimed |
| WO-2002070516-A2 | CYCLOPROPAHETEROCYCLES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MEDIVIR AB (SE) | 2002-09-12 | — | — | WO | claimed |
| US-4471123-A | Synthesis of isoxazolyl imidazolidinones | ELI LILLY AND COMPANY (US) | 1984-09-11 | — | — | US | claimed |
| JP-54046779-A | — | — | None | — | — | JP | disclosed |
| EP-3728210-B1 | ISOXAZOLE N-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2026-02-11 | — | — | EP | disclosed |
| US-12264133-B2 | Compounds, compositions and methods | CYTOKINETICS, INCORPORATED (US) | 2025-04-01 | — | — | US | disclosed |
| CN-111699180-B | Pyrazole N-linked carbamoyl cyclohexyl acid as LPA antagonist | 百时美施贵宝公司 | 2024-11-29 | — | — | CN | disclosed |
| EP-3728216-B1 | PYRAZOLE N-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2023-09-06 | — | — | EP | disclosed |
| US-11447475-B2 | Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-09-20 | — | — | US | disclosed |
| US-11384067-B2 | Pyrazole n-linked carbamoyl cyclohexyl acids as LPA antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-07-12 | — | — | US | disclosed |
| US-20220185779-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INCORPORATED | 2022-06-16 | — | — | US | disclosed |
| EP-0044185-A2 | Imidazolidinone derivatives | ELI LILLY AND COMPANY (US) | 1982-01-20 | — | — | EP | disclosed |
| US-4259501-A | Method for preparing 3-amino-5-(t-butyl)isoxazole | ELI LILLY AND COMPANY (US) | 1981-03-31 | — | — | US | disclosed |
| US-4212981-A | FROM THE ISOXAZOL-3-YL CARBOXAMIDE AND AN AMINE IN ALKALINE HYPOHALITE AND HYDROXIDE | SHIONOGI & CO., LTD. (JP) | 1980-07-15 | — | — | US | disclosed |
| US-4212981-A | FROM THE ISOXAZOL-3-YL CARBOXAMIDE AND AN AMINE IN ALKALINE HYPOHALITE AND HYDROXIDE | SHIONOGI & CO., LTD. (JP) | 1980-07-15 | — | — | US | disclosed |
| US-4212981-A | FROM THE ISOXAZOL-3-YL CARBOXAMIDE AND AN AMINE IN ALKALINE HYPOHALITE AND HYDROXIDE | SHIONOGI & CO., LTD. (JP) | 1980-07-15 | — | — | US | disclosed |
| EP-0004149-A1 | Preparation of 3-amino-5(t-butyl) isoxazole | ELI LILLY AND COMPANY (US) | 1979-09-19 | — | — | EP | disclosed |
| EP-0002881-A1 | 5-Isoxazolylurea derivatives, their preparation, their use and compositions containing them | FISONS plc (GB) | 1979-07-11 | — | — | EP | disclosed |
| JP-S5446779-A | PREPARATION OF 3-ISOXAZOLYLUREA | SHIONOGI & CO LTD | 1979-04-12 | — | — | JP | disclosed |
| US-4062861-A | HERBICIDE | SHIONOGI & CO., LTD. (JA) | 1977-12-13 | — | — | US | disclosed |