Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.39 |
| ▸ | PDE2A | O00408 | 9/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12563337 | 0.91 | PDE2A (0.41) | KLKB1ROCK2PDE2APRKG1ROCK1 | |
| SCHEMBL12563373 | 0.90 | KLKB1 (0.42) | KLKB1ROCK2PDE2APRKG1KCNQ3 | |
| SCHEMBL12563285 | 0.90 | KLKB1 (0.40) | KLKB1PDE2AKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL12563404 | 0.90 | KLKB1 (0.40) | KLKB1ROCK2PDE2APRKG1ROCK1 | |
| SCHEMBL12563286 | 0.90 | PTGER4 (0.43) | KLKB1ROCK2PDE2AKCNQ3KCNQ2 | |
| SCHEMBL12563264 | 0.89 | PDE2A (0.45) | KLKB1PDE2A | |
| SCHEMBL12563252 | 0.88 | PTGER4 (0.46) | KLKB1PDE2AKCNQ3KCNQ2 | |
| SCHEMBL12563250 | 0.88 | PDE2A (0.41) | KLKB1PDE2A | |
| SCHEMBL12563326 | 0.88 | PDE2A (0.41) | KLKB1PDE2A | |
| SCHEMBL12603590 | 0.87 | KCNQ3 (0.41) | KLKB1ROCK2PRKG1ROCK1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110152318-A1 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | AMOREPACIFIC CORPORATION (KR) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152318-A1 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | TRPV1, TRPA1, TRPV2 | KLKB1 1293/4885ROCK2 4755/4885PDE2A 1939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.