Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MLYCD | O95822 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12569385 | 0.97 | HPGD (0.69) | HPGDSMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL12569437 | 0.87 | HPGD (0.96) | HPGDSMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL18354451 | 0.85 | HPGD (1.00) | HPGDSMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL11734086 | 0.85 | HPGD (1.00) | HPGDSMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL12846471 | 0.85 | HPGD (0.54) | HPGDSMN1; SMN2KDM4EALDH1A1TSHR | |
| SCHEMBL12569628 | 0.83 | HPGD (0.89) | HPGDSMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL13495499 | 0.79 | KDM4E (0.77) | HPGDSMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL12548117 | 0.79 | HPGD (0.74) | HPGDSMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL7909422 | 0.79 | SMN1; SMN2 (0.53) | HPGDSMN1; SMN2KMT2AKDM4EALDH1A1 | |
| SCHEMBL12545688 | 0.79 | ALDH1A1 (0.54) | HPGDSMN1; SMN2KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373634-B1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MOCHIDA PHARM CO LTD (JP) | 2015-11-11 | — | — | EP | disclosed |
| US-20110135650-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2011-06-09 | — | — | US | disclosed |
| US-20110059958-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110135650-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | SERPINC1, F9, F8 | HPGD 3092/4885SMN1; SMN2 1538/4885KMT2A 1610/4885 |
| US-20110059958-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | SERPINC1, F9, F8 | HPGD 3092/4885SMN1; SMN2 1538/4885KMT2A 1610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.