Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | FLT3 | P36888 | 8/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1254931 | 0.92 | KDR (0.53) | KDRFLT3RIPK1RAB9AKMT2A | |
| SCHEMBL1257220 | 0.88 | KDR (0.57) | KDRFLT3RIPK1RAB9AKMT2A | |
| SCHEMBL1254976 | 0.86 | KDR (0.62) | KDRFLT3RIPK1RAB9AKMT2A | |
| SCHEMBL1256157 | 0.84 | RIPK1 (0.52) | KDRFLT3RIPK1RAB9AKMT2A | |
| SCHEMBL1255958 | 0.84 | KDR (0.67) | KDRFLT3RIPK1RAB9AKMT2A | |
| SCHEMBL1256029 | 0.82 | RIPK1 (0.52) | KDRFLT3RIPK1RAB9AKMT2A | |
| SCHEMBL1255968 | 0.82 | KDR (0.53) | KDRFLT3RIPK1RAB9AKMT2A | |
| SCHEMBL1257348 | 0.81 | MAPK14 (0.59) | KDRFLT3RIPK1RAB9AKMT2A | |
| SCHEMBL1256894 | 0.81 | RAB9A (0.62) | KDRFLT3RIPK1RAB9AKMT2A | |
| SCHEMBL1257359 | 0.81 | KDR (0.58) | KDRFLT3RIPK1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467137-A1 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011022473-A1 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2011-02-24 | — | — | WO | disclosed |