Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000556 | 0.89 | MDM4 (0.46) | MDM4TP53CASP3SLC17A5KMT2A | |
| SCHEMBL19899314 | 0.88 | MDM4 (0.55) | MDM4TP53CASP3SLC17A5TNF | |
| SCHEMBL29401864 | 0.88 | MDM4 (0.55) | MDM4TP53CASP3SLC17A5TNF | |
| SCHEMBL30191422 | 0.88 | MDM4 (0.55) | MDM4TP53CASP3SLC17A5TNF | |
| SCHEMBL31165326 | 0.88 | MDM4 (0.55) | MDM4TP53CASP3SLC17A5TNF | |
| SCHEMBL31000735 | 0.88 | MDM4 (0.55) | MDM4TP53CASP3SLC17A5TNF | |
| SCHEMBL13611972 | 0.88 | MDM4 (0.55) | MDM4TP53CASP3SLC17A5TNF | |
| SCHEMBL31037709 | 0.86 | MDM4 (0.49) | MDM4TP53CASP3SLC17A5TNF | |
| SCHEMBL31041158 | 0.83 | MDM4 (0.47) | MDM4TP53CASP3KMT2A | |
| SCHEMBL31000709 | 0.81 | CASP3 (0.51) | MDM4TP53CASP3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960589-B2 | Synthesis of sphingosines and their derivatives | EMORY UNIVERSITY (US) | 2011-06-14 | — | — | US | disclosed |
| US-20100197954-A1 | SYNTHESIS OF SPHINGOSINES AND THEIR DERIVATIVES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197954-A1 | SYNTHESIS OF SPHINGOSINES AND THEIR DERIVATIVES | SPHK1, SPHK2, S1PR2 | MDM4 4741/4885TP53 4169/4885CASP3 1390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.