Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.80 |
| ▸ | MEN1 | O00255 | 4/20 | 0.80 |
| ▸ | NPC1 | O15118 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.75 |
| ▸ | HPGD | P15428 | 3/20 | 0.75 |
| ▸ | HTT | P42858 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.67 |
| ▸ | PKM | P14618 | 4/20 | 0.67 |
| ▸ | USP2 | O75604 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 6/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12594549 | 0.89 | ALDH1A1 (0.76) | KMT2AMEN1NPC1ALDH1A1KDM4E | |
| SCHEMBL12595349 | 0.87 | ALDH1A1 (0.82) | KMT2AMEN1NPC1ALDH1A1KDM4E | |
| SCHEMBL12594530 | 0.87 | ALDH1A1 (0.71) | KMT2AMEN1NPC1ALDH1A1KDM4E | |
| SCHEMBL12595337 | 0.87 | ALDH1A1 (0.71) | KMT2AMEN1NPC1ALDH1A1KDM4E | |
| SCHEMBL4075910 | 0.85 | KDM4E (0.75) | KMT2AMEN1NPC1ALDH1A1KDM4E | |
| SCHEMBL2126105 | 0.82 | ALDH1A1 (0.62) | KMT2AMEN1NPC1ALDH1A1KDM4E | |
| SCHEMBL13496402 | 0.80 | KMT2A (0.83) | KMT2AMEN1NPC1ALDH1A1KDM4E | |
| SCHEMBL12594548 | 0.80 | ALDH1A1 (0.83) | KMT2AMEN1NPC1ALDH1A1KDM4E | |
| SCHEMBL13496413 | 0.79 | KMT2A (0.82) | KMT2AMEN1NPC1ALDH1A1KDM4E | |
| SCHEMBL13496406 | 0.79 | ALDH1A1 (0.80) | KMT2AMEN1NPC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546439-B2 | Small molecule inhibitors of retroviral assembly and maturation | NEW YORK BLOOD CENTER, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-8546439-B2 | Small molecule inhibitors of retroviral assembly and maturation | NEW YORK BLOOD CENTER, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20130004458-A1 | Small Molecule Inhibitors of Retroviral Assembly and Maturation | NEW YORK BLOOD CENTER, INC. (US) | 2013-01-03 | — | — | US | disclosed |
| US-20130004458-A1 | Small Molecule Inhibitors of Retroviral Assembly and Maturation | NEW YORK BLOOD CENTER, INC. (US) | 2013-01-03 | — | — | US | disclosed |
| US-8299093-B2 | Small molecule inhibitors of retroviral assembly and maturation | NEW YORK BLOOD CENTER, INC. (US) | 2012-10-30 | — | — | US | disclosed |
| US-8299093-B2 | Small molecule inhibitors of retroviral assembly and maturation | NEW YORK BLOOD CENTER, INC. (US) | 2012-10-30 | — | — | US | disclosed |
| EP-2335779-A1 | Small Molecule Inhibitors of Retroviral Assembly & Maturation | New York Blood Center (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010017355-A2 | SMALL MOLECULE INHIBITORS OF RETROVIRAL ASSEMBLY AND MATURATION | NEW YORK BLOOD CENTER (US) | 2010-02-11 | — | — | WO | disclosed |
| US-20100035912-A1 | Small Molecule Inhibitors of Retroviral Assembly and Maturation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-11 | — | — | US | disclosed |
| US-20100035912-A1 | Small Molecule Inhibitors of Retroviral Assembly and Maturation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035912-A1 | Small Molecule Inhibitors of Retroviral Assembly and Maturation | SARS1, EMG1, COPB1 | KMT2A 2466/4885MEN1 4076/4885NPC1 1423/4885 |
| US-20130004458-A1 | Small Molecule Inhibitors of Retroviral Assembly and Maturation | SARS1, EMG1, COPB1 | KMT2A 2466/4885MEN1 4076/4885NPC1 1423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.