Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.53 |
| ▸ | MEN1 | O00255 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | TP53 | P04637 | 7/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flavonol SCHEMBL28259264 | 0.83 | KDM4E (0.78) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL1259555 | 0.80 | MAPT (0.51) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL4650064 | 0.75 | MAPT (1.00) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL15456750 | 0.75 | CYP3A4 (0.82) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL1627936 | 0.75 | CYP3A4 (0.82) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| Flavonol SCHEMBL28173937 | 0.73 | KDM4E (0.85) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL74701 | 0.73 | CYP3A4 (0.74) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL5130608 | 0.72 | MAPT (0.70) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL12941005 | 0.72 | MKNK2 (0.75) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL6700894 | 0.72 | KDM4E (0.70) | MAPTKDM4ECYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948633-B1 | 3 -HYDROXYFLAVONE DERIVATIVES FOR THE DETECTION AND THE QUANTIFICATION OF CELL APOPTOSIS | CENTRE NAT RECH SCIENT (FR) | 2011-08-10 | — | — | EP | disclosed |
| US-7880021-B2 | reacting 6-bromomethyl-4'-(diethylamino)-3-hydroxyflavone with dodecylmethylamine to form the corresponding tertiary amine (4'-(diethylamino)-6-(dodecyl(methyl)aminomethyl)-3-hydroxyflavone); and reacting the product of step a. with propansultone; use in biomembrane studies; Alzheimer's disease, cancer | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2011-02-01 | — | — | US | disclosed |
| US-20090269793-A1 | Compounds and Kits for the Detection and the Quantification of Cell Apoptosis | Centre National De La Recherche Scientifiique (CNRS) | 2009-10-29 | — | — | US | disclosed |
| EP-1948633-A2 | 3 -HYDROXYFLAVONE DERIVATIVES FOR THE DETECTION AND THE QUANTIFICATION OF CELL APOPTOSIS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007057782-A2 | 3 -HYDROXYFLAVONE DERIVATIVES FOR THE DETECTION AND THE QUANTIFICATION OF CELL APOPTOSIS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090269793-A1 | Compounds and Kits for the Detection and the Quantification of Cell Apoptosis | BAX, CASP3, BCL2 | MAPT 4847/4885KDM4E 3642/4885CYP3A4 1021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.