Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.54 |
| ▸ | OGFRL1 | Q5TC84 | 12/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16407625 | 0.84 | BRD4 (0.59) | BRD4OPRM1OPRK1OGFRL1LMNA | |
| SCHEMBL9982687 | 0.83 | OPRM1 (0.60) | BRD4OPRM1OPRK1OGFRL1LMNA | |
| SCHEMBL8630899 | 0.82 | OPRM1 (0.49) | OPRM1OPRK1OGFRL1OPRD1OPRL1 | |
| SCHEMBL6196424 | 0.78 | RPS6KB1 (0.58) | OPRM1OPRK1OGFRL1LMNAOPRD1 | |
| SCHEMBL2929873 | 0.78 | RPS6KB1 (0.58) | OPRM1OPRK1OGFRL1LMNAOPRD1 | |
| SCHEMBL21148134 | 0.78 | RPS6KB1 (0.58) | OPRM1OPRK1OGFRL1LMNAOPRD1 | |
| SCHEMBL6196431 | 0.78 | RPS6KB1 (0.58) | OPRM1OPRK1OGFRL1LMNAOPRD1 | |
| SCHEMBL6198016 | 0.78 | RPS6KB1 (0.58) | OPRM1OPRK1OGFRL1LMNAOPRD1 | |
| SCHEMBL21311046 | 0.77 | RPS6KB1 (0.50) | OPRM1OPRK1OGFRL1OPRD1CCR5 | |
| SCHEMBL21310915 | 0.77 | RPS6KB1 (0.50) | OPRM1OPRK1OGFRL1OPRD1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150577-B2 | Heterocyclic compounds containing an indole core | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-06 | — | — | US | disclosed |
| US-9150577-B2 | Heterocyclic compounds containing an indole core | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-06 | — | — | US | disclosed |
| US-20130109679-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-02 | — | — | US | disclosed |
| US-20130109679-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-02 | — | — | US | disclosed |
| WO-2011071716-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109679-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BRSK2, RPS6KA2, RPS6KB2 | BRD4 710/4885OPRM1 1713/4885OPRK1 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.