Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565330 | 0.84 | SCN8A (0.48) | NSD2CA2CA1 | |
| SCHEMBL30435065 | 0.84 | KMT2A (0.54) | NSD2CA2CYP19A1CNR1ALDH1A1 | |
| SCHEMBL13240436 | 0.81 | KMT2A (0.56) | CA2CYP19A1ALDH1A1KMT2A | |
| SCHEMBL11935307 | 0.81 | RORC (0.51) | CA2PPARAKIF11CA1 | |
| SCHEMBL30605483 | 0.80 | CA2 (0.59) | NSD2CA2CYP19A1CNR1SCN3A | |
| SCHEMBL11935291 | 0.80 | FFAR1 (0.53) | CA2PPARAKIF11CA1 | |
| SCHEMBL13900224 | 0.79 | CA12 (0.61) | CA2ALDH1A1KMT2ACA1 | |
| SCHEMBL10115242 | 0.79 | HDAC3 (0.60) | CA2KMT2ACA1LSS | |
| SCHEMBL30958760 | 0.79 | CA2 (0.62) | NSD2CA2CYP19A1CNR1SCN3A | |
| SCHEMBL13959213 | 0.77 | CYP19A1 (0.63) | NSD2CA2CYP19A1CNR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |