Sugi Predict

Sugi Predict / Compounds / SCHEMBL15848980

SCHEMBL15848980

SCHEMBL15848980

C=C1CCc2c1ccc1c2c2cc(C(C)=O)c(O)cc2n1CCC1CCCN1C

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 1/20 0.63
▸ ADRA2A P08913 1/20 0.39
▸ PLK1 P53350 1/20 0.34
▸ CHRM3 P20309 8/20 0.33
▸ PRKD3 O94806 1/20 0.31
▸ PRKCG P05129 1/20 0.31
▸ PRKCB P05771 1/20 0.31
▸ PRKCA P17252 1/20 0.31
▸ PRKCH P24723 1/20 0.31
▸ PRKCI P41743 1/20 0.31
▸ PRKCE Q02156 1/20 0.31
▸ PRKCQ Q04759 1/20 0.31
▸ PRKCZ Q05513 1/20 0.31
▸ PRKCD Q05655 1/20 0.31
▸ PRKD1 Q15139 1/20 0.31
▸ ACKR3 P25106 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12608716 0.91 TP53 (0.76) TP53ADRA2APLK1CHRM3PRKD3
SCHEMBL13418930 0.91 TP53 (0.76) TP53ADRA2APLK1CHRM3PRKD3
SCHEMBL12608669 0.88 TP53 (0.82) TP53ADRA2APLK1
SCHEMBL12608668 0.88 TP53 (0.82) TP53ADRA2APLK1
SCHEMBL18328995 0.83 TP53 (0.40) TP53
SCHEMBL18975402 0.83 TP53 (0.74) TP53ADRA2APLK1CHRM3ACKR3
SCHEMBL18969209 0.83 TP53 (0.74) TP53ADRA2APLK1CHRM3ACKR3
SCHEMBL18500522 0.83 TP53 (0.48) TP53ADRA2APLK1CHRM3ACKR3
SCHEMBL12608682 0.83 TP53 (0.48) TP53ADRA2APLK1CHRM3ACKR3
SCHEMBL18969221 0.81 TP53 (0.40) TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170165229-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, INC. 2017-06-15 — — US disclosed
US-9566265-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2017-02-14 — — US disclosed
US-20150342927-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, INC. 2015-12-03 — — US disclosed
US-9108916-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2015-08-18 — — US disclosed
US-20140303224-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, LLC (US) 2014-10-09 — — US disclosed
US-8765738-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2014-07-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170165229-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 TP53 28/4885ADRA2A 3619/4885PLK1 2231/4885
US-20150342927-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 TP53 28/4885ADRA2A 3619/4885PLK1 2231/4885
US-20140303224-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 TP53 28/4885ADRA2A 3619/4885PLK1 2231/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.