Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 17/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1995409 | 0.94 | IRAK4 (0.47) | EIF2AK4IRAK4IRAK1FLT3 | |
| SCHEMBL12616146 | 0.80 | EIF2AK4 (0.49) | EIF2AK4 | |
| SCHEMBL1994957 | 0.80 | IRAK4 (0.50) | EIF2AK4IRAK4IRAK1FLT3 | |
| SCHEMBL12616048 | 0.77 | MKNK1 (0.44) | EIF2AK4IRAK4IRAK1FLT3 | |
| SCHEMBL1997583 | 0.76 | IRAK4 (0.60) | EIF2AK4IRAK4IRAK1FLT3 | |
| SCHEMBL12614076 | 0.76 | IRAK4 (0.45) | EIF2AK4IRAK4IRAK1FLT3 | |
| SCHEMBL12611701 | 0.75 | FLT3 (0.53) | FLT3 | |
| SCHEMBL2034163 | 0.75 | EIF2AK4 (0.45) | EIF2AK4IRAK4IRAK1 | |
| SCHEMBL2034164 | 0.75 | EIF2AK4 (0.45) | EIF2AK4IRAK4IRAK1 | |
| SCHEMBL13505191 | 0.75 | IRAK4 (0.50) | EIF2AK4IRAK4IRAK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |
| EP-2338888-A1 | Imidazopyridine derivatives as JAK inhibitors | Almirall, S.A. (ES) | 2011-06-29 | — | — | EP | disclosed |