Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031471 | 0.86 | KMT2A (0.44) | ALDH1A1KMT2AMEN1RAB9AKDM4E | |
| SCHEMBL316115 | 0.83 | LTA4H (0.42) | LTA4HALDH1A1KMT2ARAB9ALMNA | |
| SCHEMBL8128538 | 0.82 | MAPT (0.38) | LTA4HALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL9900619 | 0.82 | MEN1 (0.56) | ALDH1A1KMT2AMEN1RAB9AHPGD | |
| SCHEMBL314481 | 0.82 | KMT2A (0.39) | ALDH1A1KMT2AMEN1RAB9ALMNA | |
| SCHEMBL217907 | 0.82 | RAB9A (0.42) | LTA4HALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL126131 | 0.78 | — | — | |
| SCHEMBL1967426 | 0.75 | CLK4 (0.56) | CLK4ALDH1A1RAB9AKDM4EHPGD | |
| SCHEMBL8122786 | 0.74 | LMNA (0.50) | LTA4HALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL8116994 | 0.71 | ALDH1A1 (0.47) | LTA4HALDH1A1KMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |