Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27997797 | 0.95 | GAA (0.59) | MAPTGAAALDH1A1POLBLMNA | |
| SCHEMBL3664936 | 0.94 | LMNA (0.58) | MAPTGAAALDH1A1POLBLMNA | |
| SCHEMBL1720494 | 0.89 | MAPT (0.72) | MAPTGAAALDH1A1POLBHTT | |
| SCHEMBL16102147 | 0.88 | GAA (0.56) | MAPTGAAALDH1A1POLBLMNA | |
| SCHEMBL355693 | 0.84 | SMN1; SMN2 (0.58) | MAPTGAAALDH1A1POLBLMNA | |
| SCHEMBL7096747 | 0.84 | SMN1; SMN2 (0.58) | MAPTGAAALDH1A1POLBLMNA | |
| SCHEMBL5823241 | 0.83 | GAA (0.73) | MAPTGAAALDH1A1POLBLMNA | |
| SCHEMBL27926602 | 0.83 | ALDH1A1 (0.60) | ALDH1A1POLBSMN1; SMN2HTTTSHR | |
| SCHEMBL10039555 | 0.82 | ALDH1A1 (0.58) | MAPTGAAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7449135 | 0.82 | POLB (0.63) | GAAALDH1A1POLBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| EP-3952998-A1 | PYRIMIDINONE DERIVATIVES AS SHP2 ANTAGONISTS | Merck Patent GmbH (DE) | 2022-02-16 | — | — | EP | disclosed |
| WO-2020210384-A1 | PYRIMIDINONE DERIVATIVES AS SHP2 ANTAGONISTS | MERCK PATENT GMBH (DE) | 2020-10-15 | — | — | WO | disclosed |
| EP-2688872-A1 | AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES | Merck Sharp & Dohme Corp. (US) | 2014-01-29 | — | — | EP | disclosed |
| WO-2012129258-A1 | AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES | MERCK SHARP & DOHME CORP. (US) | 2012-09-27 | — | — | WO | disclosed |