Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224498 | 0.94 | HPGDS (0.40) | HPGDSALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL12620694 | 0.94 | HPGDS (0.47) | HPGDSALDH1A1SMN1; SMN2MAPTMEN1 | |
| Bromide SCHEMBL12806009 | 0.93 | HPGDS (0.39) | HPGDSALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL13576195 | 0.90 | ALDH1A1 (0.42) | HPGDSALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL12620686 | 0.90 | HPGDS (0.47) | HPGDSALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL1549933 | 0.87 | HPGDS (0.51) | HPGDSALDH1A1SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1802873 | 0.85 | HPGDS (0.50) | HPGDSALDH1A1SMN1; SMN2MEN1KMT2A | |
| Bromide SCHEMBL1801727 | 0.85 | HPGDS (0.50) | HPGDSALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2226284 | 0.84 | ALDH1A1 (0.57) | HPGDSALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL12620715 | 0.83 | HPGDS (0.52) | HPGDSALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436186-B2 | Thiazolyl piperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-05-07 | — | — | US | disclosed |
| US-20110105505-A1 | THIAZOLYL PIPERIDINE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105505-A1 | THIAZOLYL PIPERIDINE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105505-A1 | THIAZOLYL PIPERIDINE DERIVATIVES | SPHK1, S1PR1, SPHK2 | HPGDS 1318/4885ALDH1A1 1661/4885SMN1; SMN2 2628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.