Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD5 | P21918 | 2/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537158 | 0.76 | LMNA (0.35) | DRD3DRD2DRD1DRD4 | |
| SCHEMBL1299491 | 0.76 | LMNA (0.35) | DRD3DRD2DRD1DRD4 | |
| SCHEMBL9661625 | 0.76 | LMNA (0.35) | DRD3DRD2DRD1DRD4 | |
| SCHEMBL1299354 | 0.71 | KCNK3 (0.39) | — | |
| SCHEMBL327784 | 0.70 | — | — | |
| SCHEMBL2089060 | 0.70 | — | — | |
| SCHEMBL1299627 | 0.70 | — | — | |
| SCHEMBL9660196 | 0.69 | S1PR1 (0.42) | — | |
| SCHEMBL4776951 | 0.69 | S1PR1 (0.42) | — | |
| SCHEMBL13360172 | 0.69 | S1PR1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960398-B2 | Potent inhibitors of TNF activity | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-14 | — | — | US | disclosed |