SCHEMBL126258

SCHEMBL126258

Oc1cccc(NC2CCCC2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.47
TSHR P16473 1/20 0.47
RAPGEF4 Q8WZA2 1/20 0.44
KMT2A Q03164 4/20 0.43
ALDH1A1 P00352 4/20 0.43
PDK2 Q15119 1/20 0.43
CYP1A2 P05177 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
STS P08842 1/20 0.41
IDO1 P14902 1/20 0.41
LMNA P02545 2/20 0.41
MAPT P10636 2/20 0.41
MAPK1 P28482 2/20 0.41
HSD17B10 Q99714 2/20 0.41
CA12 O43570 1/20 0.41
CA2 P00918 1/20 0.41
CA5A P35218 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
CA5B Q9Y2D0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10346361 0.98 CYP3A4 (0.46) CYP3A4TSHRRAPGEF4KMT2AALDH1A1
SCHEMBL8090787 0.98 CYP3A4 (0.46) CYP3A4TSHRRAPGEF4KMT2AALDH1A1
SCHEMBL10346526 0.98 CYP3A4 (0.46) CYP3A4TSHRRAPGEF4KMT2AALDH1A1
SCHEMBL31195429 0.98 CYP3A4 (0.46) CYP3A4TSHRRAPGEF4KMT2AALDH1A1
SCHEMBL4583083 0.89 RAPGEF4 (0.41) CYP3A4TSHRRAPGEF4KMT2AALDH1A1
Cyclohexanone SCHEMBL10801298 0.87 PDK2 (0.44) CYP3A4TSHRKMT2AALDH1A1PDK2
Cycloheptanone SCHEMBL10800897 0.87 PDK2 (0.44) CYP3A4TSHRKMT2AALDH1A1PDK2
SCHEMBL3768702 0.86 KDM4E (0.46) CYP3A4TSHRKMT2AALDH1A1CYP1A2
SCHEMBL10346907 0.84 RAPGEF4 (0.45) CYP3A4TSHRRAPGEF4KMT2AALDH1A1
SCHEMBL3427795 0.84 KDM4E (0.49) CYP3A4TSHRKMT2AALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2006 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10639257-B2 Composition for colouring keratin fibres BEAUTY & BUSINESS S.P.A. (IT) 2020-05-05 US claimed
US-20190117541-A1 COMPOSITION FOR COLOURING KERATIN FIBRES BEAUTY & BUSINESS S.P.A. (IT) 2019-04-25 US claimed
US-9993413-B2 Keratin fibre dyeing composition BEAUTY & BUSINESS S.P.A. (IT) 2018-06-12 US claimed
US-20170258695-A1 KERATIN FIBRE DYEING COMPOSITION BEAUTY & BUSINESS S.P.A. (IT) 2017-09-14 US claimed
EP-3096735-A1 GRADUAL HAIRCOLOR COMPOSITIONS AND METHODS OF USING THE SAME Combe International Ltd. (US) 2016-11-30 EP claimed
WO-2015112789-A1 GRADUAL HAIRCOLOR COMPOSITIONS AND METHODS OF USING THE SAME COMBE INTERNATIONAL LTD. (US) 2015-07-30 WO claimed
EP-1789015-B1 METHOD FOR STYLISHLY CHANGING THE COLOR OF KERATINIC FIBERS HENKEL AG & CO KGAA (DE) 2014-04-23 EP claimed
EP-1778176-B1 COMPOSITION FOR COLOURING KERATIN-CONTAINING FIBRES HENKEL AG & CO KGAA (DE) 2012-07-25 EP claimed
EP-1432388-B1 AGENT FOR COLOURING FIBRES CONTAINING KERATIN HENKEL AG & CO KGAA (DE) 2008-06-18 EP claimed
US-7300472-B2 Agents for coloring fibers containing keratin HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2007-11-27 US claimed
WO-2002026201-A2 OXIDATION DYES WITH 2-AMINO-5-METHYLPHENOL HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2002-04-04 WO claimed
WO-2002026200-A1 OXIDATION DYES WITH 2-AMINO-5-METHYLPHENOL HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2002-04-04 WO claimed
EP-0853471-B1 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES, AND DYEING METHOD USING SAME OREAL (FR) 2001-10-31 EP claimed
US-6004356-A HAIR DYES L'OREAL (FR) 1999-12-21 US claimed
EP-0853471-A1 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES, AND DYEING METHOD USING SAME L'OREAL (FR) 1998-07-22 EP claimed
US-5735909-A Compositions and processes for the oxidation dyeing of keratin fibres with an oxidation base, a meta-aminophenol coupler, and a 6-hydroxyindoline coupler L'OREAL (FR) 1998-04-07 US claimed
WO-1997011674-A1 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES, AND DYEING METHOD USING SAME L'OREAL (FR) 1997-04-03 WO claimed
EP-0728465-B1 Composition for dyeing keratinous fibers comprising a meta-aminophenol and 6-hydroxyindoline, and dyeing process using such a composition OREAL (FR) 1997-03-19 EP claimed
EP-0728465-A1 Composition for dyeing keratinous fibers comprising a meta-aminophenol and 6-hydroxyindoline, and dyeing process using such a composition L'OREAL (FR) 1996-08-28 EP claimed
US-5104412-A With N-cycloalkyl-3-aminophenols as coupling compounds; colorfast brown, heat, light, chemical resistance HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1992-04-14 US claimed