Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCA | P06881 | 6/20 | 0.52 |
| ▸ | CALCRL | Q16602 | 14/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12048962 | 0.89 | CALCRL (0.50) | CALCACALCRL | |
| SCHEMBL12990698 | 0.87 | CALCRL (0.52) | CALCACALCRL | |
| SCHEMBL12049320 | 0.86 | CALCA (0.52) | CALCACALCRL | |
| SCHEMBL12049385 | 0.84 | CALCA (0.55) | CALCACALCRL | |
| SCHEMBL12990708 | 0.83 | CALCA (0.47) | CALCACALCRL | |
| SCHEMBL12990699 | 0.83 | CALCA (0.49) | CALCACALCRL | |
| SCHEMBL13083797 | 0.82 | MAPT (0.51) | CALCACALCRL | |
| SCHEMBL12049395 | 0.82 | CALCRL (0.48) | CALCACALCRL | |
| SCHEMBL12990254 | 0.81 | CALCA (0.45) | CALCACALCRL | |
| SCHEMBL12049399 | 0.81 | CALCA (0.49) | CALCACALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954268-B1 | SPIROLACTAM BICYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2012-09-26 | — | — | EP | disclosed |
| US-7947677-B2 | Spirolactam tricyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20090105219-A1 | Spirolactam Tricyclic CGRP Receptor Antagonists | MERCK SHARP & DOHME LLC | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105219-A1 | Spirolactam Tricyclic CGRP Receptor Antagonists | BDKRB1, CALCRL, BDKRB2 | CALCA 5/4885CALCRL 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.