Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.42 |
| ▸ | HPGD | P15428 | 11/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1263007 | 1.00 | KDM4E (0.50) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL1262158 | 0.91 | KDM4E (0.42) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL1262155 | 0.91 | KDM4E (0.42) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL6408127 | 0.84 | MAPT (0.37) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL6408124 | 0.84 | MAPT (0.37) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL1262723 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10ESR1 | |
| SCHEMBL1263548 | 0.76 | KDM4E (0.45) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL1263492 | 0.73 | HPGD (0.50) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL3322538 | 0.71 | GRM4 (0.46) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL3322543 | 0.71 | GRM4 (0.46) | KDM4EALDH1A1HPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884123-B2 | 3-(1H-indol-2-yl)-1H-thieno[2,3-c]pyrazole-5-(N-phenoxycarboxamide); anticancer agents; protein kinase inhibitors | AVENTIS PHARMA S.A. (FR) | 2011-02-08 | — | — | US | disclosed |
| US-20080058402-A1 | Substituted Thieno[2,3-c]pyrazoles, Process for Preparing Them, Compositions Containing Them, and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-03-06 | — | — | US | disclosed |
| US-20050026984-A1 | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products | AVENTIS PHARMA S.A. (FR) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026984-A1 | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products | TPMT, PARK7, PRNP | KDM4E 3783/4885ALDH1A1 696/4885HPGD 482/4885 |
| US-20080058402-A1 | Substituted Thieno[2,3-c]pyrazoles, Process for Preparing Them, Compositions Containing Them, and Use Thereof | TYMS, TYMP, CYP3A43 | KDM4E 3213/4885ALDH1A1 647/4885HPGD 540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.