Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1262158 | 1.00 | KDM4E (0.42) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL1263007 | 0.91 | KDM4E (0.50) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL1263008 | 0.91 | KDM4E (0.50) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL6408127 | 0.87 | MAPT (0.37) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL6408124 | 0.87 | MAPT (0.37) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL3819537 | 0.78 | KDM4E (0.38) | KDM4EALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL18542030 | 0.74 | KDM4E (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL18529056 | 0.70 | PKM (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL1262723 | 0.68 | KDM4E (0.47) | KDM4EALDH1A1HPGDPOLBHSD17B10 | |
| SCHEMBL1263548 | 0.67 | KDM4E (0.45) | KDM4EALDH1A1HPGDGLASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884123-B2 | 3-(1H-indol-2-yl)-1H-thieno[2,3-c]pyrazole-5-(N-phenoxycarboxamide); anticancer agents; protein kinase inhibitors | AVENTIS PHARMA S.A. (FR) | 2011-02-08 | — | — | US | disclosed |
| US-20080058402-A1 | Substituted Thieno[2,3-c]pyrazoles, Process for Preparing Them, Compositions Containing Them, and Use Thereof | AVENTIS PHARMA S.A. (FR) | 2008-03-06 | — | — | US | disclosed |
| EP-1824859-A1 | SUBSTITUTED THIENO[2,3-C]PYRAZOLES, METHOD FOR THE PREPARATION THEREOF, COMPOSITIONS CONTAINING THEM AND USE THEREOF | Aventis Pharma S.A. (FR) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006056697-A1 | SUBSTITUTED THIENO[2,3-C]PYRAZOLES, METHOD FOR THE PREPARATION THEREOF, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2006-06-01 | — | — | WO | disclosed |
| US-20050026984-A1 | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products | AVENTIS PHARMA S.A. (FR) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026984-A1 | Substituted thieno [2,3-c] pyrazoles and their use as medicinal products | TPMT, PARK7, PRNP | KDM4E 3783/4885ALDH1A1 696/4885HPGD 482/4885 |
| US-20080058402-A1 | Substituted Thieno[2,3-c]pyrazoles, Process for Preparing Them, Compositions Containing Them, and Use Thereof | TYMS, TYMP, CYP3A43 | KDM4E 3213/4885ALDH1A1 647/4885HPGD 540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.