SCHEMBL12630745

SCHEMBL12630745

O=NCc1ccc(-c2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.50
LMNA P02545 2/20 0.50
ABCC4 O15439 1/20 0.50
GAA P10253 1/20 0.50
TSHR P16473 1/20 0.50
PTGS1 P23219 1/20 0.50
HTT P42858 1/20 0.50
FFAR1 O14842 1/20 0.47
GRIN2B Q13224 1/20 0.46
IDO1 P14902 2/20 0.45
AGXT P21549 2/20 0.45
FAAH O00519 1/20 0.44
MGLL Q99685 1/20 0.44
ALDH1A1 P00352 3/20 0.43
MMP12 P39900 2/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
MMP13 P45452 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL249631 0.85
Hydrochloric Acid SCHEMBL11349412 0.82 CYP3A4 (0.46) TSHRGRIN2BIDO1AGXTALDH1A1
SCHEMBL12026106 0.82 MIF (0.33) LMNATSHRALDH1A1HPGD
SCHEMBL13814763 0.77 BCL2 (0.57) TAAR1LMNAIDO1AGXTMGLL
SCHEMBL6143031 0.76 TAAR1 (0.50) TAAR1LMNAABCC4GAATSHR
SCHEMBL27684886 0.76 TAAR1 (0.50) TAAR1LMNAABCC4GAATSHR
SCHEMBL5987295 0.76 TAAR1 (0.50) TAAR1LMNAABCC4GAATSHR
SCHEMBL4600494 0.76 ALDH1A1 (0.47) TAAR1LMNAABCC4GAATSHR
SCHEMBL20195110 0.74 FFAR1 (0.50) TAAR1LMNAABCC4GAATSHR
Water SCHEMBL27998963 0.74 ALDH1A1 (0.45) TAAR1LMNAABCC4GAATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2635274-B1 ANTI-STAPHYLOCOCCAL CELECOXIB DERIVATIVES UNIV OHIO STATE RES FOUND (US) 2017-12-06 EP disclosed
US-20110108793-A1 JUNCTIONS COMPRISING MOLECULAR BILAYERS FOR THE USE IN ELECTRONIC DEVICES SONY CORPORATION (JP) 2011-05-12 US disclosed