Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12670142 | 0.92 | MCL1 (0.51) | LMNAHTTKMT2AALDH1A1MAPT | |
| SCHEMBL2030698 | 0.82 | LMNA (0.41) | LMNAHTTKMT2AALDH1A1MAPT | |
| SCHEMBL2038330 | 0.79 | PPARG (0.43) | LMNAHTTALDH1A1MAPTPOLB | |
| SCHEMBL12670834 | 0.78 | ALDH1A1 (0.46) | LMNAHTTKMT2AALDH1A1MAPT | |
| SCHEMBL2036572 | 0.78 | CYP3A4 (0.49) | LMNAKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL2033632 | 0.76 | PPARG (0.45) | LMNAKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL2031128 | 0.76 | PPARG (0.48) | LMNAKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL2034300 | 0.76 | PPARG (0.45) | MAPTPOLBGAACTSD | |
| SCHEMBL2032951 | 0.75 | PPARG (0.49) | LMNAKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL2049721 | 0.75 | PPARG (0.51) | MAPTPOLBGAACTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939551-B2 | for diabetes mellitus and other metabolic disorders; compounds of given formula such as sulfonamides and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, alpha-glucosidase inhibitors, glucagon antagonists | AMGEN INC. (US) | 2011-05-10 | — | — | US | disclosed |