Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 7/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12633588 | 0.78 | RORC (0.41) | ELANESLC22A12PLAU | |
| SCHEMBL30376166 | 0.76 | TSHR (0.37) | ELANESLC22A12TSHRMEN1KMT2A | |
| SCHEMBL25175283 | 0.76 | TSHR (0.37) | ELANESLC22A12TSHRMEN1KMT2A | |
| SCHEMBL21624522 | 0.76 | TSHR (0.37) | ELANESLC22A12TSHRNPC1SMN1; SMN2 | |
| SCHEMBL4246037 | 0.74 | ENPP3 (0.34) | ELANEHSD17B10ENPP3ENPP1CNR2 | |
| SCHEMBL21624489 | 0.73 | RORC (0.35) | ELANESLC22A12TSHRPLAU | |
| SCHEMBL29771187 | 0.73 | RORC (0.35) | ELANESLC22A12TSHRPLAU | |
| SCHEMBL29482876 | 0.73 | BRAF (0.38) | ELANETSHRPLAU | |
| SCHEMBL29771186 | 0.73 | RORC (0.35) | ELANESLC22A12TSHRPLAU | |
| SCHEMBL16266430 | 0.73 | TSHR (0.35) | ELANESLC22A12TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079133-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2011-06-30 | — | — | WO | disclosed |