⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL999402 | 0.97 | — | — | |
| SCHEMBL25113460 | 0.92 | — | — | |
| SCHEMBL20233856 | 0.92 | — | — | |
| SCHEMBL25006051 | 0.92 | — | — | |
| SCHEMBL452098 | 0.92 | — | — | |
| SCHEMBL15704589 | 0.84 | — | — | |
| SCHEMBL21765789 | 0.79 | ADRB2 (0.31) | — | |
| SCHEMBL6656338 | 0.78 | — | — | |
| SCHEMBL22297368 | 0.77 | ODC1 (0.36) | — | |
| SCHEMBL10447832 | 0.77 | ODC1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10604745-B2 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule | PROMEGA CORPORATION (US) | 2020-03-31 | — | — | US | disclosed |
| US-20190085305-A1 | METHOD OF IMMOBILIZING A PROTEIN OR MOLECULE VIA A MUTANT DEHALOGENASE THAT IS BOUND TO AN IMMOBILIZED DEHALOGENASE SUBSTRATE AND LINKED DIRECTLY OR INDIRECTLY TO THE PROTEIN OR MOLECULE | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2019-03-21 | — | — | US | disclosed |
| EP-3179252-B1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORP (US) | 2018-11-14 | — | — | EP | disclosed |
| US-10101332-B2 | Covalent tethering of functional groups to proteins and substrates therefor | PROMEGA CORPORATION (US) | 2018-10-16 | — | — | US | disclosed |
| EP-3179252-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | Promega Corporation (US) | 2017-06-14 | — | — | EP | disclosed |
| EP-2395078-B1 | Covalent tethering of functional groups to proteins | PROMEGA CORP (US) | 2017-05-10 | — | — | EP | disclosed |
| US-20170097356-A1 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2017-04-06 | — | — | US | disclosed |
| EP-2395358-B1 | Covalent tethering of functional groups to proteins | PROMEGA CORP (US) | 2017-03-29 | — | — | EP | disclosed |
| US-9416353-B2 | Covalent tethering of functional groups to proteins and substrates therefor | PROMEGA CORPORATION (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150140587-A1 | METHOD OF IMMOBILIZING A PROTEIN OR MOLECULE VIA A MUTANT DEHALOGENASE THAT IS BOUND TO AN IMMOBILIZED DEHALOGENASE SUBSTRATE AND LINKED DIRECTLY OR INDIRECTLY TO THE PROTEIN OR MOLECULE | PROMEGA CORP (US) | 2015-05-21 | — | — | US | disclosed |
| US-7888086-B2 | mutant hydrolase forms stable bond with dehalogenase substrate; beta-lactamases; fusion proteins; cell labelling; tissue target therapy | PROMEGA CORPORATION (US) | 2011-02-15 | — | — | US | disclosed |
| US-20090098627-A1 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule | PROMEGA CORPORATION | 2009-04-16 | — | — | US | disclosed |
| US-20080274488-A1 | Covalent tethering of functional groups to proteins and substrates therefor | PROMEGA CORPORATION | 2008-11-06 | — | — | US | disclosed |
| US-7429472-B2 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule | PROMEGA CORPORATION | 2008-09-30 | — | — | US | disclosed |
| US-7425436-B2 | Covalent tethering of functional groups to proteins and substrates therefor | PROMEGA CORPORATION (US) | 2008-09-16 | — | — | US | disclosed |
| EP-1782071-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORPORATION (US) | 2007-05-09 | — | — | EP | disclosed |
| US-20070087400-A1 | Covalent tethering of functional groups to proteins and substrates therefor | PROMEGA CORPORATION | 2007-04-19 | — | — | US | disclosed |
| WO-2006093529-A2 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR | PROMEGA CORPORATION (US) | 2006-09-08 | — | — | WO | disclosed |
| US-20060024808-A1 | Covalent tethering of functional groups to proteins and substrates therefor | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2006-02-02 | — | — | US | disclosed |
| US-20050272114-A1 | Substrates for covalent tethering to proteins | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2005-12-08 | — | — | US | disclosed |