Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | PKM | P14618 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | TP53 | P04637 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6023094 | 0.83 | POLB (0.71) | POLBPKMMAPTTP53LMNA | |
| SCHEMBL5759940 | 0.77 | POLB (0.62) | POLBPKMMAPTTP53LMNA | |
| SCHEMBL19400889 | 0.77 | NPC1 (0.73) | POLBPKMLMNACA12CYP1A2 | |
| SCHEMBL26425790 | 0.76 | ALDH1A1 (0.65) | POLBPKMMAPTLMNAGAA | |
| SCHEMBL6022357 | 0.75 | POLB (0.60) | POLBPKMMAPTTP53GAA | |
| SCHEMBL26092765 | 0.74 | KMT2A (0.71) | POLBPKMMAPTLMNAGAA | |
| SCHEMBL12633839 | 0.73 | KMT2A (0.72) | POLBPKMMAPTLMNAALDH1A1 | |
| SCHEMBL24254522 | 0.73 | CA12 (0.63) | POLBPKMLMNACA12CYP1A2 | |
| SCHEMBL19197973 | 0.73 | SMN1; SMN2 (0.69) | POLBPKMMAPTTP53LMNA | |
| SCHEMBL117930 | 0.73 | PKM (0.65) | POLBPKMLMNACA12CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105477-A1 | COMPOSITIONS AND METHODS RELATING TO HIV PROTEASE INHIBITION | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105477-A1 | COMPOSITIONS AND METHODS RELATING TO HIV PROTEASE INHIBITION | PREP, HPN, PEPD | POLB 322/4885PKM 2276/4885MAPT 1185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.