SCHEMBL1263565

SCHEMBL1263565

Oc1ccccc1-c1cc2ccccc2c2[nH]nnc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.42
IDO1 P14902 3/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
KDM4E B2RXH2 2/20 0.42
RAB9A P51151 2/20 0.42
GAA P10253 2/20 0.42
NPC1 O15118 1/20 0.42
ALDH1A1 P00352 1/20 0.42
GLA P06280 1/20 0.42
POLB P06746 1/20 0.42
RECQL P46063 1/20 0.42
TDO2 P48775 1/20 0.42
ATM Q13315 1/20 0.42
TRPM4 Q8TD43 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
HPGD P15428 2/20 0.35
ALOX15 P16050 2/20 0.35
GUSB P08236 1/20 0.35
RIPK1 Q13546 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31017312 0.80 MAP4K4 (0.41) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL10725453 0.76 KDM4E (0.38) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL250652 0.76 KDM4E (0.33) MAPTKMT2AKDM4ERAB9AALDH1A1
SCHEMBL11438193 0.73 ALDH1A1 (0.41) MAPTIDO1MEN1KMT2ARAB9A
SCHEMBL29068872 0.73 HPRT1 (0.34) MEN1KMT2AALDH1A1HPGDUSP2
SCHEMBL7645708 0.73 CYP2A6 (0.40) MAPTMEN1KMT2AKDM4EGAA
SCHEMBL31017314 0.72 NQO1 (0.31) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL10888299 0.72 RCE1 (0.38) MEN1KMT2AALDH1A1HPGDALOX15
SCHEMBL7171942 0.71 TRPM4 (0.61) MAPTIDO1MEN1KMT2AKDM4E
SCHEMBL17573845 0.69 DYRK1A (0.52) MAPTIDO1MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8163934-B2 Ultraviolet light absorbing ketones of 2-(2-hydroxyphenyl) benzotriazole CHANG CHIA-HU (US) 2012-04-24 US disclosed
EP-2332013-A1 ULTRAVIOLET LIGHT ABSORBING KETONES OF 2-(2-HYDROXYPHENYL) BENZOTRIAZOLE Chang, Chia-Hu (US) 2011-06-15 EP disclosed
US-20110038816-A1 Ultraviolet light absorbing ketones of 2-(2-hydroxyhenyl) benzotriazole CHANG CHIA-HU 2011-02-17 US disclosed
US-7847103-B2 Ultraviolet light absorbing ketones of 2-(2-hydroxyphenyl) benzotriazole CHANG CHIA-HU 2010-12-07 US disclosed
WO-2010039229-A1 ULTRAVIOLET LIGHT ABSORBING KETONES OF 2-(2-HYDROXYPHENYL) BENZOTRIAZOLE CHANG CHIA-HU (US) 2010-04-08 WO disclosed
US-20100086500-A1 Ultraviolet light absorbing ketones of 2-(2-Hydroxyphenyl) benzotriazole CHANG CHIA-HU 2010-04-08 US disclosed
US-4129521-A Branched chain nonyl and dodecyl isomeric mixtures of 2-(5'-nonyl, or dodecyl-2'-hydroxyphenyl)benzotriazole as UV stabilizers GAF CORPORATION (US) 1978-12-12 US disclosed
US-4096242-A ULTRAVIOLET AND HEAT RESISTANCE GAF CORPORATION (US) 1978-06-20 US disclosed
US-RE29596-E Branched chain dodecyl isomeric mixtures of 2-(5-dodecyl-2-hydroxy phenyl) benzotriazole as stabilizers for heat and light sensitive materials GAF CORPORATION (US) 1978-03-28 US disclosed
US-3983132-A Branched chain dodecyl isomeric mixtures of 2-(5-dodecyl-2-hydroxy phenyl) benzotriazole as stabilizers for heat and light sensitive materials GAF CORPORATION (US) 1976-09-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110038816-A1 Ultraviolet light absorbing ketones of 2-(2-hydroxyhenyl) benzotriazole HCRTR2, HCRTR1, POLL MAPT 306/4885IDO1 1075/4885MEN1 4223/4885
US-20100086500-A1 Ultraviolet light absorbing ketones of 2-(2-Hydroxyphenyl) benzotriazole HCRTR2, HCRTR1, PAH MAPT 293/4885IDO1 1039/4885MEN1 4309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.