Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12635456 | 1.00 | KLK5 (0.50) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12635437 | 1.00 | KLK5 (0.50) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12635461 | 0.91 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12635458 | 0.91 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12635699 | 0.91 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12635691 | 0.91 | KLK5 (0.48) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12635454 | 0.90 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12635671 | 0.90 | KLK5 (0.47) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL496108 | 0.90 | KLK5 (0.57) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL496107 | 0.90 | KLK5 (0.57) | KLK5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283346-B2 | Human immunodeficiency virus protease inhibitors | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (US) | 2012-10-09 | — | — | US | disclosed |
| US-20110112068-A1 | HUMAN IMMUNODEFICIENCY VIRUS PROTEASE INHIBITORS | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112068-A1 | HUMAN IMMUNODEFICIENCY VIRUS PROTEASE INHIBITORS | SERPINB1, PREP, TMPRSS15 | KLK5 257/4885PSEN1 395/4885PSEN2 828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.