Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.54 |
| ▸ | PARP1 | P09874 | 3/20 | 0.54 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | MGAM | O43451 | 3/20 | 0.43 |
| ▸ | SI | P14410 | 3/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6368201 | 0.88 | NPC1 (0.55) | TNKSPARP1TNKS2RAB9ASMN1; SMN2 | |
| SCHEMBL13405984 | 0.87 | GAA (0.59) | TNKSPARP1TNKS2RAB9ASMN1; SMN2 | |
| SCHEMBL14091252 | 0.87 | NPC1 (0.53) | TNKSPARP1TNKS2RAB9ASMN1; SMN2 | |
| SCHEMBL6325048 | 0.87 | ALDH1A1 (0.57) | TNKSPARP1TNKS2RAB9ASMN1; SMN2 | |
| SCHEMBL13405985 | 0.87 | MGAM (0.59) | TNKSPARP1TNKS2RAB9ASMN1; SMN2 | |
| SCHEMBL5201211 | 0.85 | GAA (0.58) | RAB9ASMN1; SMN2NPC1ALDH1A1HTT | |
| SCHEMBL7945644 | 0.82 | KDM4E (0.59) | TNKSPARP1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL14115834 | 0.82 | TNKS (0.58) | TNKSPARP1TNKS2GAAMGAM | |
| SCHEMBL5201587 | 0.81 | NPC1 (0.47) | TNKSPARP1TNKS2RAB9ASMN1; SMN2 | |
| SCHEMBL6330688 | 0.81 | MMP2 (0.62) | TNKSPARP1TNKS2RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947723-B2 | Synthesis and anti-proliferative effect of benzimidazole derivatives | SPELMAN COLLEGE (US) | 2011-05-24 | — | — | US | disclosed |
| US-20090197889-A1 | SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES | SPELMAN COLLEGE (US) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197889-A1 | SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES | MKI67, PCNA, CCNI | TNKS 170/4885PARP1 138/4885TNKS2 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.