Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.56 |
| ▸ | PGR | P06401 | 5/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | SHBG | P04278 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703808 | 0.87 | SHBG (0.59) | ARPGRNR3C2ALDH1A1SERPINA6 | |
| SCHEMBL30140884 | 0.87 | SHBG (0.59) | ARPGRNR3C2ALDH1A1SERPINA6 | |
| SCHEMBL2832958 | 0.87 | SHBG (0.59) | ARPGRNR3C2ALDH1A1SERPINA6 | |
| SCHEMBL13474816 | 0.87 | AR (0.55) | ARPGRNR3C2ALDH1A1SERPINA6 | |
| SCHEMBL29335237 | 0.85 | AR (0.53) | ARPGRNR3C2ALDH1A1SERPINA6 | |
| SCHEMBL23383533 | 0.84 | SERPINA6 (0.61) | ARPGRNR3C2ALDH1A1SERPINA6 | |
| SCHEMBL13474801 | 0.84 | AR (0.55) | ARPGRNR3C2ALDH1A1SERPINA6 | |
| SCHEMBL4212652 | 0.84 | AR (0.55) | ARPGRNR3C2ALDH1A1SERPINA6 | |
| SCHEMBL10089012 | 0.84 | AR (0.55) | ARPGRNR3C2ALDH1A1SERPINA6 | |
| SCHEMBL1650166 | 0.84 | SERPINA6 (0.61) | ARPGRNR3C2ALDH1A1SERPINA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918295-B1 | Process and intermediates for the production of 7-substituted antiestrogens | ASTRAZENECA AB (SE) | 2016-04-06 | — | — | EP | disclosed |
| US-7947667-B2 | Aromatization; hydrolysis; deblocking, deprotecting; oxidation; for production of fulvestrant | ASTRAZENECA AB (SE) | 2011-05-24 | — | — | US | disclosed |
| US-7884222-B2 | protecting the 17-hydroxy group and the 3-keto group of nandrolone, then halogenating, methylating, isomerizing, dehydrogenating, reducing, oxidizing, ethynylating and deprotecting to form 17 beta -hydroxy-7 alpha -methyl-19-nor-17 alpha -pregn-5(10)-ene-20-yne-3-one | RESOLUTION CHEMICALS LIMITED (GB) | 2011-02-08 | — | — | US | disclosed |
| EP-1328538-B1 | PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF 7-SUBSTITUTED ANTIESTROGENS | ASTRAZENECA AB (SE) | 2008-08-06 | — | — | EP | disclosed |
| EP-1918295-A2 | Process and Intermediates | AstraZeneca AB (SE) | 2008-05-07 | — | — | EP | disclosed |