SCHEMBL1264030

SCHEMBL1264030

CC(C)(C)CC(C)(C)c1ccc(O)c(-n2nc3ccc(Cl)cc3n2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
MAPT P10636 3/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
KCNH2 Q12809 2/20 0.50
TP53 P04637 2/20 0.50
USP2 O75604 1/20 0.50
ESR1 P03372 1/20 0.50
PGR P06401 1/20 0.50
ADORA3 P0DMS8 1/20 0.50
AR P10275 1/20 0.50
DRD1 P21728 1/20 0.50
PTGS1 P23219 1/20 0.50
SLC6A2 P23975 1/20 0.50
PDE4A P27815 1/20 0.50
MAPK1 P28482 1/20 0.50
CASP1 P29466 1/20 0.50
SLC6A4 P31645 1/20 0.50
OPRM1 P35372 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30157198 1.00 CYP3A4 (0.50) CYP3A4SMN1; SMN2MAPTMEN1KMT2A
SCHEMBL28523920 0.89 NPC1 (0.42) CYP3A4SMN1; SMN2MAPTMEN1KMT2A
Octrizole SCHEMBL7912436 0.87 CYP3A4 (0.40) CYP3A4SMN1; SMN2MAPTMEN1KMT2A
Octrizole SCHEMBL28983126 0.86 NPC1 (0.56) CYP3A4SMN1; SMN2MAPTMEN1KMT2A
SCHEMBL29814292 0.86 NPC1 (0.46) CYP3A4SMN1; SMN2MAPTMEN1KMT2A
Octrizole SCHEMBL29349945 0.86 NPC1 (0.56) CYP3A4SMN1; SMN2MAPTMEN1KMT2A
SCHEMBL351147 0.86 NPC1 (0.46) CYP3A4SMN1; SMN2MAPTMEN1KMT2A
Octrizole SCHEMBL15508 0.86 NPC1 (0.56) CYP3A4SMN1; SMN2MAPTMEN1KMT2A
Octrizole SCHEMBL8599630 0.86 NPC1 (0.45) CYP3A4SMN1; SMN2MAPTMEN1KMT2A
SCHEMBL29356858 0.85 LMNA (0.41) CYP3A4SMN1; SMN2MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5124378-A Resin containign N-Hydroxyl hindered amine oxidative and light stabilizers CIBA-GEIGY CORPORATION (US) 1992-06-23 US claimed
US-5112890-A Piperidine compound with oxygen bonded to ring nitrogen CIBA-GEIGY CORPORATION (US) 1992-05-12 US claimed
US-5064883-A Stabilization of acid catalyzed thermoset resins with n-hydroxy hindered amines CIBA-GEIGY CORPORATION (US) 1991-11-12 US claimed
US-5006577-A Durable, weatherproof CIBA-GEIGY CORPORATION (US) 1991-04-09 US claimed
US-4426471-A TETRAALKYLPIPERIDINES CIBA-GEIGY CORPORATION (US) 1984-01-17 US claimed
US-4089839-A STABILIZERS/AGENTS UNIROYAL, INC. (US) 1978-05-16 US claimed
US-3978074-A CATALYTIC HYDROGENATION UNIROYAL INC. (US) 1976-08-31 US claimed
CN-115644556-A Cushioning element utilizing foam particles 耐克创新有限合伙公司 2023-01-31 CN disclosed
CN-115644557-A Cushioning element utilizing foam particles 耐克创新有限合伙公司 2023-01-31 CN disclosed
EP-3603609-B1 COSMETIC EMULSION COMPOSITION ADEKA CORP (JP) 2022-04-13 EP disclosed
EP-3603609-A1 COSMETIC EMULSION COMPOSITION ADEKA CORPORATION (JP) 2020-02-05 EP disclosed
CN-110290776-A METHOD FOR IMPROVING STORAGE STABILITY OF COSMETIC 株式会社ADEKA 2019-09-27 CN disclosed
US-8163934-B2 Ultraviolet light absorbing ketones of 2-(2-hydroxyphenyl) benzotriazole CHANG CHIA-HU (US) 2012-04-24 US disclosed
WO-2002012202-A2 PROCESSES FOR THE PREPARATION OF BENZOTRIAZOLE UV ABSORBERS CIBA SPECIALTY CHEMICALS HOLDINGS INC. (CH) 2002-02-14 WO disclosed
EP-1144391-A1 ONE-POT PROCESS FOR THE PREPARATION OF 5-SULFONYL-SUBSTITUTED BENZOTRIAZOLES Ciba SC Holding AG (CH) 2001-10-17 EP disclosed
WO-2000043376-A1 ONE-POT PROCESS FOR THE PREPARATION OF 5-SULFONYL-SUBSTITUTED BENZOTRIAZOLES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-07-27 WO disclosed
US-6040455-A REACTING A HALOBENZOTRIAZOLE COMPOUND WITH ALIPHATIC, PHENYLALKYL OR ARYL MERCAPTAN COMPOUND TO FORM 5-THIO SUBSTITUTED BENZOTRIAZOLE, OXIDIZING WITH HYDROGEN PEROXIDE TO FOR 5-SULFONE SUBSTITUED BENZOTRIAZOLE COMPOUND CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-03-21 US disclosed
US-4089839-A STABILIZERS/AGENTS UNIROYAL, INC. (US) 1978-05-16 US disclosed
US-4089839-A STABILIZERS/AGENTS UNIROYAL, INC. (US) 1978-05-16 US disclosed
US-3978074-A CATALYTIC HYDROGENATION UNIROYAL INC. (US) 1976-08-31 US disclosed